Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Urinary Tract Infection II: Pathophysiology01:25

Urinary Tract Infection II: Pathophysiology

1.1K
The pathophysiology of urinary tract infections (UTIs) encompasses several progressive stages, beginning with bacterial colonization and culminating in potential systemic complications if untreated. UTIs are primarily initiated by bacteria, such as Escherichia coli, which often originate from the gastrointestinal tract and migrate to the urinary system through the periurethral area. This migration can occur via several routes, including improper hygiene practices, sexual activity, or...
1.1K
Urinary Tract Infection I: Introduction01:26

Urinary Tract Infection I: Introduction

1.0K
Urinary tract infections (UTIs) impact various parts of the urinary system, including the kidneys, ureters, bladder, and urethra. These infections are generally bacterial, with Escherichia coli being the most common causative agent, often originating from the gastrointestinal tract. However, other bacteria, such as Staphylococcus saprophyticus, Klebsiella pneumoniae, and Proteus mirabilis, are also known to cause UTIs. The type, location, and underlying complexity of the UTI guide both...
1.0K
Acute Pyelonephritis I: Introduction01:27

Acute Pyelonephritis I: Introduction

1.1K
Pyelonephritis is a bacterial infection that primarily affects the renal parenchyma and collecting system, including the renal pelvis, tubules, and interstitial tissue of one or both kidneys. It can be classified as either acute—a sudden, severe infection—or chronic, which refers to long-term or recurrent kidney infections.The primary cause of acute pyelonephritis (APN) is bacterial infection, with Escherichia coli accounting for approximately 70-80% of cases. Other bacteria, such...
1.1K
Microbiota of the Urogenital Tract01:28

Microbiota of the Urogenital Tract

18
The human urogenital system, once thought to be sterile in healthy individuals, is now recognized as a complex microbial habitat. Advancements in molecular sequencing techniques have revealed that even in healthy adults, the kidneys and bladder harbor microbial populations similar to those found in the distal urethra, albeit in much lower abundance. These resident microorganisms, while generally innocuous, can become opportunistic pathogens under conditions that alter the urogenital...
18
Urinary Tract Infection III: Diagnostic Studies and Interprofessional Care01:30

Urinary Tract Infection III: Diagnostic Studies and Interprofessional Care

392
A healthcare provider can diagnose a urinary tract infection (UTI) through several methods:Medical History and Symptoms: The provider will take a detailed medical history and ask about symptoms such as frequent urination, burning sensation during urination, and lower abdominal pain.Urinalysis: A clean-catch urine sample is collected in a sterile container and tested for the presence of bacteria, white blood cells (leukocytes), nitrites, blood, and protein. The presence of leukocytes and...
392
Disorders of the Urinary System01:20

Disorders of the Urinary System

1.9K
The urinary system is responsible for eliminating waste and excess fluids from the body. However, disorders of the urinary system can arise due to various reasons like infections, stress, age, congenital abnormalities, and lifestyle.
Urinary tract infections (UTIs) are one of the most common urinary system disorders. They are caused by bacteria that enter the urethra and can spread to the bladder resulting in cystitis. Pyelonephritis is the result of a UTI that has ascended to the level of the...
1.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Real-time digital monitoring of continuous bladder irrigation: clinical evaluation of a sensor-based system for hematuria and catheter-associated events.

Frontiers in digital health·2025
Same author

Long-term follow-up of "three horse shoe-like incision (3-HSI) holmium laser enucleation of the prostate: outcomes and efficacy of a novel en-bloc technique for anatomic transurethral prostatectomy".

BMC urology·2025
Same author

Multivariable regression analysis of perioperative parameters for a novel pulsed solid-state Thulium: YAG laser with high peak power versus Holmium: YAG laser in prostate enucleation.

World journal of urology·2025
Same author

Holmium laser enucleation of the prostate and strictures: long-term outcomes, stricture characteristics, and risk factors.

World journal of urology·2025
Same author

Pembrolizumab plus enzalutamide and androgen deprivation therapy versus placebo plus enzalutamide and androgen deprivation therapy for metastatic hormone-sensitive prostate cancer: the randomized, double-blind, phase III KEYNOTE-991 study.

Annals of oncology : official journal of the European Society for Medical Oncology·2025
Same author

Open versus robotic-assisted partial nephrectomy in patients with intermediate/high-complexity kidney tumours: final results of the randomised, controlled, open-label, multicentre trial OpeRa.

Annals of oncology : official journal of the European Society for Medical Oncology·2025

Related Experiment Video

Updated: Mar 23, 2026

Establishment and Characterization of UTI and CAUTI in a Mouse Model
08:40

Establishment and Characterization of UTI and CAUTI in a Mouse Model

Published on: June 23, 2015

21.2K

[Current Aspects on the Pathogenesis of Urinary Tract Infections].

G Magistro1, J Marcon1, V Beck1

  • 1Urologische Klinik und Poliklinik der Universität München, Ludwig-Maximilians-Universität München.

Aktuelle Urologie
|March 24, 2016
PubMed
Summary

Urinary tract infections (UTIs) are common, but antibiotic resistance is rising. Understanding how bacteria and the body interact is key to developing new UTI treatments and combating drug-resistant pathogens.

More Related Videos

An In Vitro Bladder Model of Catheter-Associated Urinary Tract Infection
07:57

An In Vitro Bladder Model of Catheter-Associated Urinary Tract Infection

Published on: June 24, 2025

1.4K
Transurethral Induction of Mouse Urinary Tract Infection
09:24

Transurethral Induction of Mouse Urinary Tract Infection

Published on: August 5, 2010

37.5K

Related Experiment Videos

Last Updated: Mar 23, 2026

Establishment and Characterization of UTI and CAUTI in a Mouse Model
08:40

Establishment and Characterization of UTI and CAUTI in a Mouse Model

Published on: June 23, 2015

21.2K
An In Vitro Bladder Model of Catheter-Associated Urinary Tract Infection
07:57

An In Vitro Bladder Model of Catheter-Associated Urinary Tract Infection

Published on: June 24, 2025

1.4K
Transurethral Induction of Mouse Urinary Tract Infection
09:24

Transurethral Induction of Mouse Urinary Tract Infection

Published on: August 5, 2010

37.5K

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Immunology

Background:

  • Urinary tract infections (UTIs) are a global health concern, frequently affecting women.
  • Antibiotics are the current standard treatment, but rising antimicrobial resistance poses a significant therapeutic challenge.
  • A lack of new antimicrobial drugs exacerbates the problem, necessitating novel treatment strategies.

Purpose of the Study:

  • To explore the intricate host-pathogen interactions in UTIs.
  • To identify key bacterial virulence factors and host responses involved in UTI pathogenesis.
  • To inform the development of new therapeutic approaches against UTIs.

Main Methods:

  • This study reviews current literature on UTI pathogenesis, focusing on bacterial virulence mechanisms.
  • It examines host immune responses to uropathogenic bacteria.
  • The review synthesizes findings on intracellular bacterial communities and recurrent infections.

Main Results:

  • Uropathogenic bacteria employ diverse virulence factors to establish infection.
  • Intracellular bacterial communities allow pathogens to evade host defenses and promote recurrence.
  • Host responses target specific bacterial virulence mechanisms crucial for pathogenicity.

Conclusions:

  • Understanding host-pathogen interactions is critical for developing novel UTI treatments.
  • Targeting bacterial virulence factors and host responses offers a promising avenue for combating antibiotic-resistant UTIs.
  • Further research into molecular mechanisms is essential for effective therapeutic innovation.