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PhotoCORMs: CO release moves into the visible
Mark A Wright1, Joseph A Wright1
1Energy Materials Laboratory, School of Chemistry, University of East Anglia, Norwich NR4 7TJ, UK. joseph.wright@uea.ac.uk.
Dalton Transactions (Cambridge, England : 2003)
|March 24, 2016
Summary
Carbon monoxide (CO) shows therapeutic potential. New photo-activated CO-releasing molecules (photoCORMs) offer controlled CO delivery using visible light, advancing therapeutic applications.
Area of Science:
- Chemistry
- Photochemistry
- Medicinal Chemistry
Background:
- Carbon monoxide (CO) is recognized for its therapeutic potential.
- Controlled CO delivery is crucial for therapeutic applications, often achieved via CO-releasing molecules (CORMs).
- PhotoCORMs, which release CO upon light irradiation, are a key area of development.
Purpose of the Study:
- To review the evolution of photoCORMs.
- To highlight recent advancements in visible-light-activated photoCORMs.
- To discuss the design principles and applications of photoCORMs.
Main Methods:
- Review of scientific literature on metal carbonyl photophysics and photoCORM development.
- Analysis of recent research on visible-light-responsive photoCORMs.
- Examination of the design strategies for photoCORMs.
Main Results:
- Metal carbonyl complexes can release CO under UV irradiation.
- Significant progress has been made in developing photoCORMs activated by visible light.
- PhotoCORMs operating in the visible spectrum are now achievable.
Conclusions:
- PhotoCORMs represent a significant advancement in controlled CO delivery for therapeutic purposes.
- The development of visible-light photoCORMs expands their potential applications.
- Continued research in photoCORM design promises further therapeutic innovations.
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