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Updated: Mar 23, 2026
Murine Model of Leukemia Relapse to Induction Chemotherapy for Acute Lymphoblastic Leukemia
Published on: October 17, 2025
Outcome of children and adolescents with lymphoblastic lymphoma
Maria Christina Lopes Araújo Oliveira1, Keyla Christy Sampaio1, Aline Carneiro Oliveira2
1Department of Pediatrics, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
Insights
Children with lymphoblastic lymphoma (LBL) treated with intensive chemotherapy derived from acute lymphoblastic leukemia (ALL) therapy show a favorable prognosis. Most patients achieve remission and long-term survival, highlighting treatment effectiveness.
Area of Science:
- Pediatric Oncology
- Hematology
- Lymphoma Research
Background:
- Lymphoblastic lymphoma (LBL) is a significant pediatric non-Hodgkin lymphoma subtype.
- Characterizing the clinical course of pediatric LBL is crucial for treatment optimization.
Purpose of the Study:
- To analyze the clinical course and outcomes of pediatric and adolescent LBL patients treated at a tertiary care center.
- To evaluate the effectiveness of intensive chemotherapy regimens derived from acute lymphoblastic leukemia (ALL) therapy in LBL.
Main Methods:
- Retrospective cohort study of 27 pediatric patients (≤16 years) with LBL diagnosed between 1981 and 2013.
- Diagnosis confirmed via tumor biopsy and/or pleural fluid cytology.
- Overall survival analyzed using Kaplan-Meier method; treatment utilized ALL-derived chemotherapy.
Main Results:
- Median age at diagnosis was 11.6 years; 59% had T-cell origin LBL, commonly involving the mediastinum.
- 67% presented with advanced disease; 89% achieved complete remission.
- At median 43-month follow-up, 81% were alive in first remission; 5-year survival for de novo LBL was 78%.
Conclusions:
- Intensive chemotherapy regimens adapted from ALL therapy yield a favorable prognosis for pediatric LBL.
- The study confirms the efficacy of this treatment approach in achieving high remission and survival rates in children with LBL.
Introduction:
lymphoblastic lymphoma (LBL) is the second most common subtype of non-Hodgkin lymphoma in children. The aim of this study was to characterize the clinical course of children and adolescents with LBL treated at a tertiary center.
Methods:
this is a retrospective cohort study of 27 patients aged 16 years or less with LBL admitted between January 1981 and December 2013. Patients received intensive chemotherapy regimen derived from acute lymphoblastic leukemia (ALL) therapy. Diagnosis was based on biopsy of tumor and/or cytological examination of pleural effusions. The overall survival was analyzed using the Kaplan-Meier method.
Results:
the median age at diagnosis was 11.6 years (interquartile range, 4.6-13.8). LBL had T cell origin in 16 patients (59%). The most common primary manifestation in T-cell LBL was mediastinum involvement in 9 patients (56%). Intra-abdominal tumor was the major site of involvement in patients with pB-LBL. Most patients had advanced disease (18 patients - 67%) at diagnosis. Twenty-four patients (89%) achieved complete clinical remission. After a median follow-up of 43 months (interquartile range, 6.4-95), 22 patients (81%) were alive in first complete remission. Five children (18.5%) died, three of them soon after admission and two after relapsing. The probability of survival at five years for 20 patients with de novo LBL was 78% (SD 9.4).
Conclusion:
our findings confirm the favorable prognosis of children with LBL with an intensive chemotherapy regimen derived from ALL therapy.
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