[PECULIARITIES OF ERYTHROPOIETIN SYNTHESIS CIRCADIAN RHYTHM IN PATIENTS WITH ESSENTIAL ARTERIAL HYPERTENSION]

Area of Science:

• Cardiovascular Medicine
• Endocrinology
• Hematology

Background:

• Erythropoietin (ERO) regulates erythroid cell development and has receptors in cardiovascular tissues.
• Essential arterial hypertension (EAH) is a condition with potential cardiovascular complications.
• Understanding ERO's role in cardiovascular health is crucial.

Purpose of the Study:

• To investigate circadian rhythm patterns in erythropoietin (ERO) synthesis.
• To assess the predictive value of serum ERO level variations for cardiovascular complications in stage II EAH patients.
• To explore correlations between ERO, neopterin, interleukin-1, and CD34 cells in EAH.

Main Methods:

• Measured serum levels of erythropoietin (ERO), neopterin, and interleukin-1 in 200 patients with stage II EAH.
• Analyzed circadian rhythm variations of ERO synthesis.
• Correlated ERO levels and their diurnal changes with cardiovascular complication risk, CD34 cell counts, and neopterin levels.

Main Results:

• Patients with stage II EAH exhibited elevated ERO levels compared to normal values.
• Lack of nighttime ERO level reduction was associated with an increased probability of cardiovascular complications.
• This lack of reduction correlated with decreased CD34 cell counts and increased neopterin levels.

Conclusions:

• Circadian rhythm disturbances in ERO synthesis may predict cardiovascular complications in EAH.
• The findings suggest potential, yet unknown, effects of ERO on the cardiovascular system.
• Further research is warranted to explore ERO's therapeutic applications in EAH management.