ANTIBACTERIAL AND ANTIOXIDANT ACTIVITY OF METHANOLIC EXTRACT OF ZALEYA PENTANDRA

The objective of this study was to evaluate the antibacterial and antioxidant activity of methanolic extract of Zaleya pentandra. It inhibited the growth of S. typhi, with zone of inhibition 13 mm at concentration 3 mg/100 µL and 11 mm at concentration 1.5 mg/100 µL. It also showed zone of inhibition against S. aureus with 17.5 mm and 12.5 mm at concentration 3 mg/100 µL in comparison to erythromycin with 15.6 mm. It showed 73% radical scavenging at concentration 161 µL/mL. The extract was fractioned by column chromatography using eluents (chloroform:methanol:H₂O). The isolation and purification afforded amorphous solid which was subjected to physical, chemical and spectral techniques UV, IR, ¹H-NMR, ¹³C-NMR and HREI-MS for the structure elucidation of the isolated compound. The compound was named pentandraol. From the present study, it was concluded that the methanolic extract of Zaleya pentandra has antibacterial and antioxidant activity and contains a novel compound named as pentandraol.