Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Clinical Trials: Overview01:11

Clinical Trials: Overview

5.4K
Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
5.4K
Clinical Trials01:16

Clinical Trials

11.1K
Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
11.1K
Crossover Experiments01:16

Crossover Experiments

4.7K
Crossover experiments, also called the repeated-measurements design, is a study design in which all experimental units are exposed to all treatments in different periods. Crossover experiments are generally used in psychology, the pharmaceutical industry, agriculture, and medicine.
Crossover designs are performed even with smaller sample sizes since the samples can act as their controls. These are better than simple randomized trials since patients are exposed to all the treatments.
4.7K
Bioavailability Study Design: Healthy Subjects Versus Patients01:15

Bioavailability Study Design: Healthy Subjects Versus Patients

202
Bioavailability studies are essential for evaluating a drug's therapeutic efficacy and understanding its absorption patterns under various physiological conditions. Conducting such studies on target patient populations provides more relevant data by simulating real-world disease states. However, practical challenges often necessitate the use of young, healthy adult volunteers as study subjects.Patients may exhibit altered drug absorption patterns due to the effects of the disease itself,...
202

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Retrospective chart review of immobilized lipase cartridge use in children with short bowel syndrome.

Journal of pediatric gastroenterology and nutrition·2026
Same author

Lessons of Macrophage-Associated Heart Regeneration in Fish, Amphibians, and Neonatal Mice, Applied to Adult Mice: A Perspective on α-Gal Nanoparticles.

International journal of molecular sciences·2026
Same author

Development of a registry to evaluate immobilized lipase cartridge use in pediatric patients with short bowel syndrome/intestinal failure.

Intestinal Failure (New York, N.Y.)·2026
Same author

Real-World Evidence of Growth Improvement in Children 1 to 5 Years of Age Receiving Enteral Formula Administered Through an Immobilized Lipase Cartridge.

Nutrients·2026
Same author

Firearm Disqualification and Rights Restoration Among Adults with Mental Illness in Virginia.

The journal of the American Academy of Psychiatry and the Law·2025
Same author

The Association of Aortic Stenosis Severity and Symptom Status With Morbidity and Mortality.

JACC. Advances·2025

Related Experiment Video

Updated: Mar 23, 2026

A New Single Chamber Implantable Defibrillator with Atrial Sensing: A Practical Demonstration of Sensing and Ease of Implantation
16:40

A New Single Chamber Implantable Defibrillator with Atrial Sensing: A Practical Demonstration of Sensing and Ease of Implantation

Published on: February 28, 2012

27.0K

The ixCELL-DCM Trial: Rationale and Design.

Timothy D Henry1, Gary L Schaer, Anthony DeMaria

  • 1Cedars-Sinai Heart Institute, Los Angeles, CA, USA.

Cell Transplantation
|March 25, 2016
PubMed
Summary

Ixmyelocel-T, a cell therapy from bone marrow, is being tested in a large trial for ischemic dilated cardiomyopathy. This study evaluates its safety and effectiveness in improving heart failure outcomes.

More Related Videos

A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition
04:53

A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition

Published on: September 20, 2019

11.4K
Expedited Radiation Biodosimetry by Automated Dicentric Chromosome Identification ADCI and Dose Estimation
10:33

Expedited Radiation Biodosimetry by Automated Dicentric Chromosome Identification ADCI and Dose Estimation

Published on: September 4, 2017

16.7K

Related Experiment Videos

Last Updated: Mar 23, 2026

A New Single Chamber Implantable Defibrillator with Atrial Sensing: A Practical Demonstration of Sensing and Ease of Implantation
16:40

A New Single Chamber Implantable Defibrillator with Atrial Sensing: A Practical Demonstration of Sensing and Ease of Implantation

Published on: February 28, 2012

27.0K
A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition
04:53

A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition

Published on: September 20, 2019

11.4K
Expedited Radiation Biodosimetry by Automated Dicentric Chromosome Identification ADCI and Dose Estimation
10:33

Expedited Radiation Biodosimetry by Automated Dicentric Chromosome Identification ADCI and Dose Estimation

Published on: September 4, 2017

16.7K

Area of Science:

  • Regenerative Medicine
  • Cardiovascular Research
  • Cell Therapy

Background:

  • Ischemic dilated cardiomyopathy (IDCM) significantly impacts heart function and quality of life.
  • Previous studies suggested potential benefits of intramyocardial ixmyelocel-T in IDCM patients.
  • A robust clinical trial is needed to confirm efficacy and safety.

Purpose of the Study:

  • To assess the efficacy, safety, and tolerability of ixmyelocel-T in patients with heart failure due to IDCM.
  • To evaluate the impact of ixmyelocel-T on clinical, functional, and quality of life outcomes.
  • To establish the potential of cell therapy as a treatment for IDCM.

Main Methods:

  • A randomized, double-blinded, placebo-controlled phase 2b trial (ixCELL-DCM) involving 114 patients.
  • Patients received catheter-based transendocardial injection of ixmyelocel-T or placebo.
  • Primary endpoint: composite of death, cardiovascular hospitalizations, or unplanned clinic visits over 12 months.

Main Results:

  • The study is ongoing, and results are pending.
  • Analysis of primary and secondary endpoints will determine treatment efficacy.
  • Safety and tolerability data will be crucial for future development.

Conclusions:

  • The ixCELL-DCM trial represents a significant advancement in cell therapy research for heart failure.
  • Results will inform the potential role of ixmyelocel-T in managing IDCM.
  • This study contributes valuable data to the field of regenerative medicine for cardiovascular diseases.