Related Experiment Video
Updated: Mar 23, 2026
Orthotopic Implantation and Peripheral Immune Cell Monitoring in the II-45 Syngeneic Rat Mesothelioma Model
Published on: October 2, 2015
Immune response profiling of malignant pleural mesothelioma for diagnostic and prognostic biomarkers
Jenette Creaney1,2, Ian M Dick3, A W Bill Musk4,5
1a National Centre for Asbestos Related Diseases, School of Medicine and Pharmacology, University of Western Australia , Perth , Western Australia , Australia ;
Abstract:
The asbestos induced cancer malignant mesothelioma (MM) is difficult to diagnose and has a poor prognosis. MM is an immunological cancer, therefore autoantibodies may be suitable biomarkers and associated with prognosis. We used Protoarray(®) microarrays to determine immune responses to 8798 antigens in 10 MM and 10 asbestos exposed controls and developed diagnostic panels using 17 antigens from this. The AUC of these panels were independently tested in these 10 MM patients and controls and in a validation group of 36 controls and 35 MM patients using luminex assays; none of the antigens identified were validated. Immune responses to RAB38 were associated with a better prognosis.
