Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Role of Hippocampus in Memory

Role of Hippocampus in Memory

The hippocampus, a critical brain structure, plays an essential role in memory processing, particularly in the formation and retrieval of memory. This small, seahorse-shaped region is located within the medial temporal lobe, with one hippocampus in each brain hemisphere. Experimental studies involving lesions in the hippocampi of rats have demonstrated significant impairments in tasks such as object recognition and maze navigation, indicating the hippocampus involvement in both recognition and...

Cerebral Hemispheres

Cerebral Hemispheres

The human brain, a complex organ, is functionally divided into two cerebral hemispheres—left and right. These hemispheres are interconnected by a structure of paramount importance, the corpus callosum. This substantial bundle of neural fibers is not just a bridge between the hemispheres but a crucial element for the brain's comprehensive functioning. It enables efficient communication between the two hemispheres, allowing each side of the brain to control and receive sensory and motor...

Lateralization

Lateralization

Brain lateralization refers to the division of mental processes and functions between the two hemispheres of the brain, a phenomenon that optimizes neural efficiency and underpins complex abilities in humans. This specialization allows each hemisphere to perform tasks where it has a comparative advantage, facilitating more refined cognitive capabilities across different domains.

Association Areas of the Cortex

Association Areas of the Cortex

Association areas are regions of the cerebral cortex that do not have a specific sensory or motor function. Instead, they integrate and interpret information from various sources to enable higher cognitive processes such as memory, learning, and decision-making. Some key association areas include the following:
Prefrontal Association Area: This area is located in the frontal lobe and is involved in planning, decision-making, and moderating social behavior. It connects with primary motor areas,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Stage-specific Healthcare Burden of Fall-related Injuries Among Older Adults in Korea.

Journal of preventive medicine and public health = Yebang Uihakhoe chi·2026

Same author

Renal Dysfunction Modifies the Prognostic Value of Lactate Clearance in Extracorporeal Cardiopulmonary Resuscitation: A Retrospective Interaction Analysis.

Journal of cardiothoracic and vascular anesthesia·2026

Same author

Sulfonation-Time-Dependent Structure-Property Relationships of Electrospun Polyketone Nanofiber Membranes for PEMFC Applications.

Polymers·2026

Same author

Human amygdala-like telencephalic organoids model stress circuitry in assembloid systems.

Cell stem cell·2026

Same author

AlphaGenome: a framework for integrated regulatory variant interpretation.

International journal of biological sciences·2026

Same author

Multimodal AI mapping with GigaTIME reveals spatial immune signaling states in the tumor microenvironment.

International journal of biological sciences·2026

Search research articles

Related Experiment Video

Updated: Mar 23, 2026

Author Spotlight: Investigating the Effects of Mind-Body-Movement Practices on Brain Function

Author Spotlight: Investigating the Effects of Mind-Body-Movement Practices on Brain Function

Published on: January 26, 2024

Functional cross-hemispheric shift between object-place paired associate memory and spatial memory in the human

Choong-Hee Lee¹, Jungwon Ryu¹, Sang-Hun Lee¹

¹Department of Brain and Cognitive Sciences, Seoul National University, Seoul, Korea.

|March 25, 2016

Summary

The left and right hippocampi show distinct roles in memory and navigation. The left hippocampus is crucial for object-place memory, while the right supports spatial navigation, revealing hemispheric specialization.

Keywords:

hemispheric lateralization object-place paired association retrieval efficiency spatial memory virtual reality

More Related Videos

Assessment of Memory Function in Pilocarpine-induced Epileptic Mice

Assessment of Memory Function in Pilocarpine-induced Epileptic Mice

Published on: June 4, 2020

The Spatial Memory Game: Testing the Relationship Between Spatial Language, Object Knowledge, and Spatial Cognition

The Spatial Memory Game: Testing the Relationship Between Spatial Language, Object Knowledge, and Spatial Cognition

Published on: February 19, 2018

Related Experiment Videos

Last Updated: Mar 23, 2026

Author Spotlight: Investigating the Effects of Mind-Body-Movement Practices on Brain Function

Author Spotlight: Investigating the Effects of Mind-Body-Movement Practices on Brain Function

Published on: January 26, 2024

Assessment of Memory Function in Pilocarpine-induced Epileptic Mice

Assessment of Memory Function in Pilocarpine-induced Epileptic Mice

Published on: June 4, 2020

The Spatial Memory Game: Testing the Relationship Between Spatial Language, Object Knowledge, and Spatial Cognition

The Spatial Memory Game: Testing the Relationship Between Spatial Language, Object Knowledge, and Spatial Cognition

Published on: February 19, 2018

Area of Science:

Neuroscience
Cognitive Psychology
Neuroimaging

Background:

The hippocampus is vital for spatial navigation and object-based memory.
Hemispheric specialization within the human hippocampus for these functions remains unclear.

Purpose of the Study:

To investigate functional asymmetry between the left and right hippocampi in humans.
To differentiate hippocampal roles in object-place memory versus spatial navigation.

Main Methods:

Used functional magnetic resonance imaging (fMRI) to measure BOLD activity.
Subjects performed object-place associative memory and spatial navigation tasks in a virtual environment.
Analyzed BOLD responses during object-cueing and object-cued place recognition periods.

Main Results:

BOLD activity shifted from the left to the right hippocampus as task demands changed.
Left hippocampal activity correlated with efficient object-place memory retrieval.
Right hippocampal activity correlated with efficient spatial memory retrieval.

Conclusions:

Suggests that the left and right hippocampi process different types of information for episodic memory in space.
Highlights potential hemispheric specialization within the human hippocampus for distinct cognitive functions.