Pharmacogenetic Testing: Application in Mental Health Prescribing
Elizabeth Burke1, Rene Love2, Pam Jones3
11 Elizabeth Burke, DNP, PMHNP, Vanderbilt University School of Nursing, Nashville, TN, USA.
Pharmacogenetic testing (PGT) helps personalize psychiatric medication by analyzing genetic variations for better drug response. This approach moves beyond trial-and-error prescribing, improving treatment efficacy and reducing side effects.
Area of Science:
- Pharmacogenomics
- Psychiatric pharmacology
- Clinical genetics
Background:
- Current psychiatric medication management often relies on trial-and-error prescribing.
- Pharmacogenetic testing (PGT) offers a genetic approach to optimize drug selection.
- PGT identifies individual genetic variability influencing drug response, aiming for maximal efficacy and minimal side effects.
Purpose of the Study:
- To provide background on pharmacogenetic testing (PGT).
- To explain the principles of drug metabolism relevant to PGT.
- To evaluate the impact and application of PGT in clinical settings.
Main Methods:
- Literature review of articles published since 2010.
- Searches conducted on PubMed and ProQuest databases.
- Focus on studies involving PGT in clinical nursing settings.
Main Results:
- Advancements in biotechnology have reduced the cost of genetic sequencing.
- PGT is becoming more accessible and applicable in clinical practice.
- Despite rising healthcare costs, PGT offers a cost-effective approach to personalized medicine.
Conclusions:
- Pharmacogenetic testing (PGT) is increasingly prevalent in healthcare.
- Nurses require knowledge of PGT's purpose, potential, and limitations.
- Informed nurses can provide accurate patient information regarding PGT for psychiatric medications.
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