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Treatment options for apnoea of prematurity

Sarah U Morton1, Vincent C Smith2

  • 1Harvard Neonatal-Perinatal Fellowship Program, Boston Children's Hospital Boston, Boston, Massachusetts, USA.

Archives of Disease in Childhood. Fetal and Neonatal Edition
|March 25, 2016
PubMed

Insights

Apnoea of prematurity (AOP) affects extremely preterm infants. Effective treatments, including standard therapies and emerging options, are crucial for optimizing care and preventing negative outcomes in these vulnerable newborns.

Area of Science:

  • Neonatal Medicine
  • Pediatric Pulmonology

Background:

  • Apnoea of prematurity (AOP) is a common condition in infants born before 28 weeks gestation or weighing less than 1000g.
  • Untreated AOP can lead to adverse outcomes in preterm infants.

Purpose of the Study:

  • To review the pathophysiology of AOP.
  • To discuss associated conditions linked to AOP.
  • To outline current and emerging treatment options for AOP.

Main Methods:

  • Literature review of pathophysiology, associated conditions, and treatments for AOP.
  • Synthesis of information on standard therapies (xanthine, respiratory support).
  • Inclusion of novel therapeutic approaches like stochastic vibrotactile stimulation and new pharmaceutical agents.

Main Results:

  • AOP pathophysiology involves immature respiratory control mechanisms.
  • Associated conditions can complicate AOP management.
  • A range of treatments exist, from established methods to innovative interventions.

Conclusions:

  • Effective management of AOP is vital for improving preterm infant outcomes.
  • Standard treatments like xanthine therapy and respiratory support remain important.
  • Emerging therapies offer expanded options for AOP treatment.

Keywords:
Apnea of prematurityIntensive care, neonatalreview article

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