Related Experiment Video

Updated: Mar 23, 2026

Establishment of a Rat Model of Superior Sagittal-Sinus Occlusion via a Thread-Embolism Method
08:07

Establishment of a Rat Model of Superior Sagittal-Sinus Occlusion via a Thread-Embolism Method

Published on: July 4, 2021

4.1K

Cerebral venous sinus thrombosis in the patient with multiple sclerosis associated with congenital antithrombin

Yuhei Kanaya1, Kazuhiro Takamatsu, Yutaka Shimoe

  • 1Department of Neurology, and Department of Radiology, Brain Attack Center Ota Memorial Hospital.

Rinsho Shinkeigaku = Clinical Neurology
|March 25, 2016
PubMed

Insights

This case study highlights a young man with multiple sclerosis who developed cerebral venous sinus thrombosis. Genetic analysis revealed a rare antithrombin deficiency, a potential risk factor for thrombosis in MS patients.

Area of Science:

  • Neurology
  • Genetics
  • Hematology

Background:

  • Multiple sclerosis (MS) is a chronic autoimmune disease affecting the central nervous system.
  • Cerebral venous sinus thrombosis (CVST) is a rare but serious complication that can occur in MS patients.
  • Antithrombin deficiency is a genetic condition predisposing individuals to thrombotic events.

Observation:

  • A 25-year-old male with a history of optic neuritis and relapsing-remitting MS presented with severe headache and unconsciousness.
  • Initial MRI suggested an MS exacerbation, but subsequent imaging revealed cerebral venous sinus thrombosis.
  • Laboratory tests showed low antithrombin activity, and genetic analysis identified a heterozygous mutation in the antithrombin gene.

Findings:

  • The patient's presentation of CVST in the context of MS was unusual.
  • Genetic analysis confirmed a heterozygous antithrombin gene mutation (C>T at codon 359), indicating a hereditary thrombophilia.
  • Literature review identified 17 cases of MS associated with CVST, with several linked to lumbar puncture and methylprednisolone treatment.

Implications:

  • This case underscores the importance of considering thrombotic events in MS patients presenting with neurological symptoms, especially those with risk factors.
  • Antithrombin deficiency may represent an underrecognized risk factor for CVST in multiple sclerosis.
  • Further research is warranted to elucidate the complex interplay between MS, genetic thrombophilias, and treatment modalities in the development of CVST.

More Related Videos

Comprehensive Endovascular and Open Surgical Management of Cerebral Arteriovenous Malformations14:58

Comprehensive Endovascular and Open Surgical Management of Cerebral Arteriovenous Malformations

Published on: October 20, 2017

10.4K

Related Concept Videos

Venous Thrombosis I: Introduction01:30

Venous Thrombosis I: Introduction

Venous thrombosis, the most common disorder of the veins, involves the formation of a thrombus or blood clot associated with vein inflammation. It can be classified as either superficial vein thrombosis or deep vein thrombosis.Superficial Vein Thrombosis: This involves the formation of a thrombus in a superficial vein, usually the greater or lesser saphenous vein. Though less severe than deep vein thrombosis (DVT), SVT can lead to complications if untreated.Deep Vein Thrombosis (DVT): This...
666
Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies01:20

Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies

The key difference between Superficial Vein Thrombosis (SVT) and Deep Vein Thrombosis (DVT) lies in their location and severity.Clinical ManifestationsSVT typically presents with localized pain, tenderness, and redness along the course of a superficial vein, often accompanied by a palpable, cord-like structure under the skin. This condition is usually less dangerous than DVT but can be uncomfortable and may lead to complications such as cellulitis or, rarely, a clot extension into the deep...
432
Venous Thrombosis III: Interprofessional Care01:29

Venous Thrombosis III: Interprofessional Care

Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
459
Overview of Systemic Veins01:11

Overview of Systemic Veins

Systemic veins are crucial blood vessels that return deoxygenated blood from various body tissues back to the heart. There are three systemic veins that return deoxygenated blood to the heart, they are as follows.
The coronary sinus, the heart's principal vein, resides in the coronary sulcus on the heart's posterior aspect. This broad venous channel receives nearly all venous blood from the myocardium, the heart muscle. It is fed by three primary veins: the great cardiac vein, the...
1.7K
Anticoagulant Drugs: Low-Molecular-Weight Heparins01:30

Anticoagulant Drugs: Low-Molecular-Weight Heparins

Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
2.3K
Veins of Head and Neck01:19

Veins of Head and Neck

The blood drainage from the head and neck is primarily managed by three pairs of veins: the external jugular, internal jugular, and vertebral veins. The external jugular veins drain superficial scalp and face structures, passing over the sternocleidomastoid muscles to empty into the subclavian veins.
On the other hand, the vertebral veins, unlike their arterial counterparts, are not primarily responsible for brain drainage. Instead, they drain the cervical vertebrae, spinal cord, and some small...
6.8K