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Published on: May 22, 2020
Photothermal ablation of cancer cells using self-doped polyaniline nanoparticles
Yoochan Hong1, Wonseok Cho2, Jeonghun Kim1
1Department of Radiology, College of Medicine, Yonsei University, Seoul 03722, Korea.
Abstract:
Water-stable confined self-doping polyaniline nanocomplexes are successfully fabricated by nano-assembly using lauric acid both as a stabilizer and as a localized dopant. In particular, the colloidal stability of the polyaniline nanocomplexes in neutral pH and the photothermal potential by near-infrared light irradiation are characterized. We demonstrate that confined self-doping polyaniline nanocomplexes as a photothermal nanoagent are preserved in the doped state even at a neutral pH. Finally, confined self-doping polyaniline nanocomplexes aided by lauric acid are successfully applied for the photothermal ablation of cancer cells.

