Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Poly(A) metabolism and aging: a current view.

W E Müller1, R Wenger, M Bachmann

  • 1Institut für Physiologische Chemie, Mainz University, F.R.G.

Archives of Gerontology and Geriatrics
|November 1, 1989
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Brainstem auditory evoked responses in horses with hearing loss and during general anesthesia].

Schweizer Archiv fur Tierheilkunde·2024
Same author

FLT3-directed UniCAR T-cell therapy of acute myeloid leukaemia.

British journal of haematology·2023
Same author

Patient and health provider costs of integrated HIV, diabetes and hypertension ambulatory health services in low-income settings - an empirical socio-economic cohort study in Tanzania and Uganda.

BMC medicine·2021
Same author

Personal and occupational experiences of COVID-19 and their effects on South African health workers' wellbeing.

South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde·2021
Same author

Polyphosphate (PolyP) for alveolar cleft repair: study protocol for a pilot randomized controlled trial.

Trials·2021
Same author

[Weaning in a Pandemic Situation - A Position Paper].

Pneumologie (Stuttgart, Germany)·2020
Same journal

Post-intervention effectiveness of a computerized personalized cognitive stimulation program adapted according to cognitive reserve in older adults without cognitive impairment in Primary Care: A randomized clinical trial.

Archives of gerontology and geriatrics·2026
Same journal

Corrigendum to "Loneliness trajectories and long-term frailty in the english longitudinal study of ageing: The mediating role of depression". Archives of Gerontology and Geriatrics 2026Jul:146:106210.

Archives of gerontology and geriatrics·2026
Same journal

Corrigendum to "Updating knowledge on existing approaches on advanced care planning interventions: An umbrella review" [Archives of Gerontology and Geriatrics 148 (2026) 106255].

Archives of gerontology and geriatrics·2026
Same journal

Exercise-responsive Wnt/β-catenin signaling across metabolic tissues during aging: A narrative review.

Archives of gerontology and geriatrics·2026
Same journal

Attention as a potentially responsive cognitive outcome in a community-based multidomain dementia prevention program (the community-adapted J-MINT Brain Health Program in Kikuyo Town, Japan).

Archives of gerontology and geriatrics·2026
Same journal

Trajectories of physical function during a 12-week resident-led health promotion program (HATSURATSU) among community-dwelling older adults in Japan.

Archives of gerontology and geriatrics·2026
See all related articles

Cellular aging involves changes in poly(A) tail synthesis, a crucial step in gene expression. This review examines how poly(A) tail length affects mRNA stability and distribution during the aging process.

Area of Science:

  • Molecular Biology
  • Gene Expression Regulation
  • Cellular Aging

Background:

  • Polyadenylation of messenger RNA (mRNA) is a critical post-transcriptional modification.
  • This process significantly influences gene expression control within cells.
  • Age-dependent alterations in polyadenylation are implicated in cellular senescence.

Purpose of the Study:

  • To review the role of poly(A) tail synthesis in cellular aging.
  • To discuss the impact of poly(A) tails on mRNA stability during aging.
  • To explore how poly(A) sequences affect mRNA localization in aging cells.

Main Methods:

  • Literature review of studies on polyadenylation and aging.
  • Analysis of the function of poly(A) tails in mRNA metabolism.

Related Experiment Videos

  • Examination of age-related changes in poly(A) synthesis and mRNA dynamics.

    • Main Results:

    • Poly(A) tail length is a key determinant of mRNA stability.
    • Changes in polyadenylation impact the intracellular distribution of mRNA.
    • Age-dependent alterations in poly(A) synthesis contribute to cellular aging.

    Conclusions:

    • Polyadenylation is a crucial factor in post-transcriptional gene regulation.
    • Age-related changes in poly(A) synthesis play a significant role in cellular aging.
    • The poly(A) tail influences mRNA stability and localization, impacting aging phenotypes.