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Updated: Mar 23, 2026

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Coenzyme B12 Repurposed for Photoregulation of Gene Expression
Karl Gruber1, Bernhard Kräutler2
1Institute of Molecular Biosciences, University of Graz, Humboldtstraße 50/3, 8010, Graz, Austria. karl.gruber@uni-graz.at.
None:
Old cofactor, new tricks: In enzymes, coenzyme B12 has a well-known function as a radical initiator through homolysis of the Co-C bond. It has recently been shown that nature has repurposed this cofactor as a photosensitive switch for the regulation of bacterial carotenoid biosynthesis. Co-C bond breakage is again the key event in this process, triggering huge conformational changes in the B12 -binding protein.
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