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Serum homocysteine as a risk factor for carotid intimal thickening in acute stroke: A cross sectional observational

Anup J Devasia1, Binu Joy2, Subhash D Tarey3

  • 1Department of Hematology, Christian Medical College, Vellore, Tamil Nadu, India.

Annals of Indian Academy of Neurology
|March 25, 2016
PubMed

Insights

High homocysteine (Hcy) levels correlate with carotid intima-medial thickening (CIMT) in stroke patients. This finding suggests Hcy may help predict atherothrombotic events.

Area of Science:

  • Neurology
  • Cardiovascular Medicine
  • Biochemistry

Background:

  • Stroke is a leading cause of disability and mortality.
  • Carotid intima-medial thickness (CIMT) is an indicator of atherosclerosis.
  • Homocysteine (Hcy) is an amino acid linked to cardiovascular disease.

Purpose of the Study:

  • To investigate the correlation between serum homocysteine levels and CIMT in patients with acute anterior circulation strokes.
  • To determine if Hcy can serve as a predictor of atherothrombotic events.

Main Methods:

  • A study of 100 consecutive acute anterior circulation stroke patients.
  • Measurement of fasting serum homocysteine levels within 24 hours of admission.
  • Carotid Doppler scans to estimate CIMT on both sides.

Main Results:

  • A significant positive correlation was found between serum homocysteine levels and CIMT (r = 0.409, p = 0.000).
  • Elevated homocysteine levels accounted for 60% of the variation in CIMT after controlling for other risk factors.

Conclusions:

  • Serum homocysteine levels are strongly correlated with CIMT.
  • Homocysteine may be a valuable biomarker for predicting atherothrombotic events in stroke patients.
Abstract

Keywords:
Homocysteineatherosclerosiscarotid intima-medial thicknessstroke

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