Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Amniochorion: immunologic aspects--a review.

J S Hunt1, J L Fishback

  • 1Department of Pathology, University of Kansas Medical Center, Kansas City 66103.

American Journal of Reproductive Immunology (New York, N.Y. : 1989)
|November 1, 1989
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A True Positive and a False Negative? The Dilemma of Negative Colonoscopy After a Positive Fecal Occult Blood Test.

Digestive diseases and sciences·2021
Same author

IFPA Senior Award Lecture: Reproductive immunology in perspective--reprogramming at the maternal-fetal interface.

Placenta·2013
Same author

Immunomodulatory molecules are released from the first trimester and term placenta via exosomes.

Placenta·2012
Same author

Expression and localization of messenger RNA for tumor necrosis factor receptor (TNF-R) I and TNF-RII in pregnant mouse uterus and placenta.

Endocrine·2010
Same author

Typhoid fever; a treatment failure with streptomycin.

American practitioner and digest of treatment·2010
Same author

Streptomycin in clinical practice; a review and case reports.

American practitioner and digest of treatment·2010
Same journal

Silibinin Modulates NF-κB Activation and Heat Shock Protein in Preeclampsia-Like Rat Model.

American journal of reproductive immunology (New York, N.Y. : 1989)·2026
Same journal

Proinflammatory and Antiangiogenic Effects of Gingival Crevicular Fluid on Placental and Immune Cells: Implications for Oxidative Stress and NET Formation in Pregnancy.

American journal of reproductive immunology (New York, N.Y. : 1989)·2026
Same journal

Comment on "Assessing the Impact of Female Genital Mutilation/Cutting on Genital Inflammation and Microbiota Among Kenyan Female sex Workers".

American journal of reproductive immunology (New York, N.Y. : 1989)·2026
Same journal

Targeting Long Noncoding RNA LUCAT1 Alleviates Insulin Resistance of Ovarian Granulosa Cells in Polycystic Ovary Syndrome by Blocking HMGB1-Mediated Autophagy.

American journal of reproductive immunology (New York, N.Y. : 1989)·2026
Same journal

A Comparative Analysis of the Immunoglobulin G and M Antibodies Seroprevalence Against Helicobacter pylori, Toxoplasma gondii, and Cytomegalovirus in Women With Preeclampsia.

American journal of reproductive immunology (New York, N.Y. : 1989)·2026
Same journal

Platelet Rich Plasma: Pioneering a Paradigm Shift in Subclinical Endometritis Treatment.

American journal of reproductive immunology (New York, N.Y. : 1989)·2026
See all related articles

Trophoblast cells in pregnancy may avoid maternal immune attack by uniquely regulating human leukocyte antigen (HLA) gene expression. This mechanism might also be used by tumor cells to evade immune responses.

Area of Science:

  • Immunology
  • Reproductive Biology
  • Cellular Biology

Background:

  • Pregnancy involves genetically distinct maternal and fetal cells coexisting.
  • Chorionic cytotrophoblast cells contact maternal cells, expressing paternally derived human leukocyte antigen (HLA) that should trigger rejection.
  • However, maternal immune cells do not infiltrate the extraplacental membranes.

Purpose of the Study:

  • To investigate the gene expression of trophoblast cells.
  • To elucidate mechanisms enabling maternal-fetal cell coexistence during pregnancy.
  • To understand why maternal immune cells do not attack the placenta.

Main Methods:

  • In situ hybridization
  • Northern blotting
  • Molecular studies of gene expression

Related Experiment Videos

Main Results:

  • Trophoblast cells may selectively transcribe class I HLA genes.
  • Trophoblast cells might process HLA gene products differently than other cell types.
  • These regulatory mechanisms may prevent maternal immune attack on the placenta.

Conclusions:

  • Selective regulation of class I HLA gene expression is a potential mechanism for trophoblast cells to avoid maternal immune rejection.
  • This HLA regulation strategy may be shared by some tumor cells to evade host immune responses.
  • Understanding trophoblast HLA regulation offers insights into immune tolerance during pregnancy and cancer immunology.