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Increased Postexercise Lipoxin A4 Levels in Exhaled Breath Condensate in Asthmatic Children With Exercise-Induced
Journal of Investigational Allergology & Clinical Immunology
|March 26, 2016
Summary
Exhaled breath condensate lipoxin A4 (LXA4) increased after exercise in asthmatic children with exercise-induced bronchoconstriction (EIB). This suggests LXA4 may help reduce airway inflammation and bronchoconstriction in EIB.
Area of Science:
- Pulmonary Medicine
- Immunology
- Pediatrics
Background:
- Lipoxins are potential inflammation modulators in the lungs.
- The role of exhaled breath condensate lipoxin A4 (LXA4) in asthmatic children with exercise-induced bronchoconstriction (EIB) remains uninvestigated.
Purpose of the Study:
- To investigate the involvement of EBC LXA4 in EIB.
- To determine if EBC LXA4 levels change following exercise challenge in asthmatic children.
Main Methods:
- Study included 45 asthmatic children (5-17 years).
- Patients were grouped by positive (n=17) or negative (n=28) response to exercise.
- LXA4 levels in exhaled breath condensate (EBC) were measured pre- and post-exercise using ELISA.
Main Results:
- EBC LXA4 levels significantly increased post-exercise in children with a positive EIB response (P=.05).
- No significant changes in EBC LXA4 were observed in children with a negative EIB response (P>.05).
- An inverse correlation was found between LXA4 levels and FEV1% reduction post-exercise (P=.05, r=-0.50).
Conclusions:
- EBC LXA4 levels rise immediately after exercise in asthmatic children exhibiting EIB.
- Hypothesized that increased airway LXA4 compensates for bronchoconstriction and suppresses inflammation.
- LXA4 may contribute to spontaneous bronchodilation following EIB.
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