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Adipokines and Migraine: A Systematic Review
B Lee Peterlin1, Simona Sacco2, Claudia Bernecker3,4
1Johns Hopkins University School of Medicine, Department of Neurology, Baltimore, MD, USA.
Headache
|March 26, 2016
Summary
While research suggests a link between migraine and adipokines, proteins from fat tissue, current evidence is inconclusive due to study variations. Further research is needed to clarify the role of adipokines in migraine.
Area of Science:
- Neuroendocrinology
- Metabolic Syndrome
- Headache Disorders
Background:
- Migraine frequently co-occurs with obesity.
- Adipocytokines, secreted by adipose tissue, influence energy balance and inflammation.
- Adipose tissue functions as a neuroendocrine organ.
Purpose of the Study:
- To review the association between migraine and obesity.
- To systematically review literature on adiponectin and leptin levels in migraine patients.
Main Methods:
- PubMed database search for "migraine," "adiponectin," and "leptin."
- Inclusion of English language studies from 2005-2015.
- Review of reference lists for relevant articles.
Main Results:
- Existing data suggest a potential association between adipokines and migraine.
- Conflicting results and study design heterogeneity limit definitive conclusions.
Conclusions:
- Further research with rigorous methodology is required.
- Systematic characterization of pain, demographics, and covariates is essential.
- Investigate adipokines as potential migraine biomarkers or therapeutic targets.
