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Updated: Mar 23, 2026

Phase Behavior of Charged Vesicles Under Symmetric and Asymmetric Solution Conditions Monitored with Fluorescence Microscopy

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Published on: October 24, 2017

A two phase field model for tracking vesicle-vesicle adhesion.

Rui Gu¹, Xiaoqiang Wang², Max Gunzburger²

¹Department of Scientific Computing, Florida State University, Tallahassee, FL, 32306-4120, USA. rg10e@fsu.edu.

Journal of Mathematical Biology

|March 26, 2016

Summary

This summary is machine-generated.

This study introduces a multi-phase-field model to simulate vesicle adhesion, offering insights into cellular interactions and potential applications in endocytosis and multi-cell adhesion simulations.

Keywords:

Elastic bending energy Endocytosis Energetic variational formulation Erythrocyte rouleaux Fast Fourier transform Lipid bilayer Phase-field model Three-dimensional simulations Vesicle membranes

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Area of Science:

Computational biology
Biophysics
Materials science

Background:

Vesicle adhesion is crucial for many biological processes.
Simulating these interactions requires robust computational models.

Purpose of the Study:

To develop and validate a multi-phase-field model for simulating vesicle adhesion.
To explore the model's applicability to endocytosis and multi-cell adhesion.

Main Methods:

A multi-phase-field model using two phase field functions for each vesicle.
An energy model incorporating elastic bending and contact potential energies.
Penalty method for imposing vesicle volume and surface area constraints.

Main Results:

The model successfully simulates different types of vesicle contact.
Numerical results validate the model's efficacy and provide visual illustrations.
The model demonstrates potential for simulating endocytosis and erythrocyte rouleaux.

Conclusions:

The developed multi-phase-field model is effective for simulating vesicle adhesion.
The model is adaptable for studying endocytosis and complex multi-cell adhesions.
Comparison with laboratory observations confirms the model's effectiveness.