Related Experiment Video

Updated: Jul 23, 2026

Hippocampal Insulin Microinjection and In vivo Microdialysis During Spatial Memory Testing
10:32

Hippocampal Insulin Microinjection and In vivo Microdialysis During Spatial Memory Testing

Published on: January 11, 2013

[Bioelectric activity of the brain in insulin-induced hypoglycemia in children with growth deficiency]

L Szewczyk, C Dobosz-Latalska, B Niewiedzioł

    Pediatria Polska
    |July 1, 1989
    PubMed

    Insights

    Insulin-induced hypoglycemia can cause abnormal brain activity (EEG) in children with growth deficiency. Younger children with severe growth issues and low somatotropin levels showed more pronounced EEG changes.

    Area of Science:

    • Pediatric Endocrinology
    • Neurophysiology

    Background:

    • Growth deficiency in children is a significant concern.
    • Insulin-induced hypoglycemia is a common test for growth hormone assessment.
    • Brain bioelectric activity (EEG) can be affected by metabolic changes.

    Purpose of the Study:

    • To assess somatotropin levels during insulin-induced hypoglycemia in children with growth deficiency.
    • To evaluate the correlation between glycemia, somatotropin activity, and brain activity (EEG).

    Main Methods:

    • Assessed somatotropin levels in 30 children with growth deficiency.
    • Monitored glycemia and brain bioelectric activity (EEG) for 120 minutes during insulin-induced hypoglycemia.
    • Correlated EEG findings with glucose levels and somatotropin activity.

    Main Results:

    • 90% of children exhibited generalized and paroxysmal EEG abnormalities during hypoglycemia.
    • EEG abnormalities exacerbated with maximal glucose decrease.
    • Early and intense EEG abnormalities were more frequent in younger children with severe growth deficiency and low somatotropin.

    Conclusions:

    • Insulin-induced hypoglycemia can trigger significant EEG abnormalities in children with growth deficiency.
    • The severity of EEG changes correlates with glucose decline and somatotropin levels.
    • Age and severity of growth deficiency are factors influencing EEG response to hypoglycemia.

    More Related Videos

    Studying the Hypothalamic Insulin Signal to Peripheral Glucose Intolerance with a Continuous Drug Infusion System into the Mouse Brain08:32

    Studying the Hypothalamic Insulin Signal to Peripheral Glucose Intolerance with a Continuous Drug Infusion System into the Mouse Brain

    Published on: January 4, 2018

    Measurement of Insulin- and Contraction-Stimulated Glucose Uptake in Isolated and Incubated Mature Skeletal Muscle from Mice08:01

    Measurement of Insulin- and Contraction-Stimulated Glucose Uptake in Isolated and Incubated Mature Skeletal Muscle from Mice

    Published on: May 16, 2021

    Related Concept Videos

    Hormones Regulating Blood Glucose01:16

    Hormones Regulating Blood Glucose

    Insulin is released by beta cells of the pancreas when blood glucose levels are high. It facilitates glucose absorption and utilization in insulin-dependent cells with insulin receptors on their plasma membranes. Insulin promotes glucose uptake by increasing the number of glucose transport proteins in the cell membrane, allowing glucose to enter the cell. As a result, glucose utilization and ATP production are enhanced.
    In addition to accelerating glucose uptake and utilization, insulin has...
    Diabetes Mellitus: Overview and Type I Subtype01:22

    Diabetes Mellitus: Overview and Type I Subtype

    Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
    Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
    Glucose Homeostasis: Pancreatic Islets and Insulin Secretion01:27

    Glucose Homeostasis: Pancreatic Islets and Insulin Secretion

    The pancreatic islets comprising only 1%-2% of the volume are highly vascularized and innervated mini-organs. They contain five endocrine cell types, including β cells that secrete insulin, which is synthesized as a single polypeptide chain, preproinsulin, processed to proinsulin, and finally to insulin and C-peptide. This process is complex and regulated, involving the Golgi complex, the endoplasmic reticulum, and the secretory granules of the β cell.
    Insulin and C-peptide are co-secreted in...
    Hypoglycemia and Glucagon01:15

    Hypoglycemia and Glucagon

    Without prolonged fasting, healthy individuals maintain blood glucose levels above 3.5 mM due to a well-adapted neuroendocrine counterregulatory system that effectively prevents acute hypoglycemia, a potentially life-threatening condition. The primary clinical scenarios for hypoglycemia encompass diabetes treatment, inappropriate production of endogenous insulin or insulin-like substances by tumors, and the use of glucose-lowering agents in non-diabetic individuals. Notably, hypoglycemia in the...
    Type I Diabetes II: Pathophysiology01:26

    Type I Diabetes II: Pathophysiology

    Type 1 diabetes mellitus arises from an immune-mediated destruction of pancreatic β-cells, resulting in an absolute deficiency of insulin. This process develops in genetically susceptible individuals when autoimmunity, environmental exposures, and immunologic dysregulation converge to trigger a targeted attack on the insulin-producing cells of the pancreas. The β-cells are located within the islets of Langerhans and are essential for regulating blood glucose by facilitating cellular uptake of...
    Hypoglycemia01:26

    Hypoglycemia

    Hypoglycemia is a blood glucose level below 70 mg/dL. It commonly occurs in individuals using insulin or insulin-secreting drugs, but may also arise in non-diabetic conditions. People with type 1 diabetes are at the highest risk because they depend on exogenous insulin. People with type 2 diabetes are also at risk, especially when treated with insulin or medications such as sulfonylureas, which increase insulin release regardless of blood glucose levels. It develops when insulin levels exceed...