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Updated: Mar 23, 2026

Assessment of Morphine-induced Hyperalgesia and Analgesic Tolerance in Mice Using Thermal and Mechanical Nociceptive Modalities
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Melatonin reverses morphine tolerance by inhibiting microglia activation and HSP27 expression

Sheng-Hsiung Lin1, Ya-Ni Huang2, Jen-Hsin Kao3

  • 1Graduate Institute of Medical Science, National Defense Medical Center, Taipei City, Taiwan; Medical Service Office, Tri-Service General Hospital Songshang Branch, Taipei City, Taiwan.

Life Sciences
|March 26, 2016
PubMed
Abstract

Keywords:
AntinociceptionHeat shock protein 27Intrathecal injectionMelatoninMicroglial activationMorphine toleranceNeuroinflammationTail-flick latency

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