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Draft Genome Sequences of Two Extensively Drug-Resistant Acinetobacter baumannii Strains Isolated from Pus Samples

Niranjana Mahalingam1, Bhavani Manivannan2, Sudhir Jadhao3

  • 1Department of Microbiology, Sri Sathya Sai Institute of Higher Medical Sciences, Prasanthigram, India.

Genome Announcements
|March 26, 2016
PubMed

Insights

We sequenced the genomes of two extensively drug-resistant (XDR) Acinetobacter baumannii strains from surgical site infections in India. This provides insights into the genetic makeup of these challenging pathogens.

Area of Science:

  • Microbiology
  • Genomics
  • Infectious Diseases

Background:

  • Extensively drug-resistant (XDR) Acinetobacter baumannii poses a significant global health threat, particularly in healthcare settings.
  • Surgical site infections (SSIs) are a common complication, and XDR strains complicate treatment options.

Purpose of the Study:

  • To perform whole-genome sequencing of two XDR Acinetobacter baumannii strains.
  • To analyze the genomic characteristics of strains isolated from patients with SSIs in India.

Main Methods:

  • Whole-genome sequencing was performed on two Acinetobacter baumannii isolates (AB28 and AB30).
  • Genomic size and G+C content were determined for each strain.

Main Results:

  • The draft genomes of two XDR Acinetobacter baumannii strains were successfully generated.
  • Both strains exhibited an average genomic size of approximately 4 Mbp.
  • The G+C content was found to be 38.96% for AB28 and 38.94% for AB30.

Conclusions:

  • The genomic data provides a foundation for understanding the genetic basis of drug resistance in these Acinetobacter baumannii strains.
  • This study contributes valuable genomic information on XDR pathogens from an Indian healthcare setting.

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