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Related Experiment Video

Updated: Mar 23, 2026

Continuous Fluorescence-Based Endonuclease-Coupled DNA Methylation Assay to Screen for DNA Methyltransferase Inhibitors

Continuous Fluorescence-Based Endonuclease-Coupled DNA Methylation Assay to Screen for DNA Methyltransferase Inhibitors

Published on: August 5, 2022

Ectopic DNMT3B expression delays leukemogenesis.

Robert F Stanley¹, Ulrich Steidl¹

¹ALBERT EINSTEIN COLLEGE OF MEDICINE.

|March 26, 2016

Summary

This summary is machine-generated.

Increased DNA methyltransferase 3B (DNMT3B) expression prolonged survival in mouse leukemia models. However, high DNMT3B target gene expression in acute myeloid leukemia (AML) patients correlated with worse survival outcomes.

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Efficient Purification and LC-MS/MS-based Assay Development for Ten-Eleven Translocation-2 5-Methylcytosine Dioxygenase

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Last Updated: Mar 23, 2026

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Efficient Purification and LC-MS/MS-based Assay Development for Ten-Eleven Translocation-2 5-Methylcytosine Dioxygenase

Efficient Purification and LC-MS/MS-based Assay Development for Ten-Eleven Translocation-2 5-Methylcytosine Dioxygenase

Published on: October 15, 2018

Area of Science:

Hematology
Epigenetics
Cancer Biology

Background:

DNA methylation is a crucial epigenetic mechanism regulating gene expression.
Aberrant DNA methylation patterns are implicated in the development of various cancers, including leukemia.
The role of DNA methyltransferase 3B (DNMT3B) in leukemogenesis requires further elucidation.

Purpose of the Study:

To investigate the impact of DNMT3B-mediated DNA methylation on leukemogenesis using a mouse model.
To determine the correlation between DNMT3B expression and survival outcomes in acute myeloid leukemia (AML) patients.

Main Methods:

Utilized a tetracycline-inducible Dnmt3b knock-in mouse model.
Induced leukemia using retroviral vectors (Myc-Bcl2 or MLL-AF9).
Analyzed DNMT3B expression levels and DNMT3B target gene expression in patient samples.

Main Results:

Increased DNMT3B expression led to prolonged survival in retrovirally induced Myc-Bcl2– or MLL-AF9–driven leukemia models.
Acute myeloid leukemia (AML) patients with high expression of DNMT3B target genes exhibited inferior overall survival.
DNMT3B plays a complex role in leukemia, potentially promoting survival in certain contexts while being associated with poor prognosis in others.

Conclusions:

DNMT3B has a dual role in leukemia pathogenesis, influencing both disease progression and patient survival.
Targeting DNMT3B or its downstream pathways may offer therapeutic strategies for AML.
Further research is warranted to fully understand the epigenetic landscape of leukemia and identify effective therapeutic targets.