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Updated: Mar 23, 2026

A Precision Medicine Tool for Measurement and Monitoring of Hemoglobin S in Sickle Cell Disease Patients Receiving Transfusion Therapy
Assessing the Accuracy of Reporting of Maternal Red Blood Cell Transfusion at Birth Reported in Routinely Collected
Jillian A Patterson1, Sally Francis2, Jane B Ford3
1Clinical and Population Perinatal Health Research, Kolling Institute, University of Sydney, c/- University Dept of O&G, Building 52, Royal North Shore Hospital, St Leonards, NSW, 2065, Australia. jillian.patterson@sydney.edu.au.
Hospital administrative data accurately captures most red blood cell transfusions in maternity patients, with high reliability for large volume transfusions. However, some underreporting occurs, especially in regional hospitals.
Area of Science:
- Healthcare Informatics
- Transfusion Medicine
- Obstetrics
Background:
- Hospital administrative data is frequently used to analyze transfusion practices in maternity populations.
- Accurate data is crucial for interpreting transfusion study results.
Purpose of the Study:
- To compare the accuracy of hospital administrative data reporting for red cell transfusions around childbirth against blood bank records.
- To assess the sensitivity and specificity of hospital data for identifying transfusions.
Main Methods:
- Linked hospital and birth data from New South Wales, Australia (June 2006-December 2010).
- Comparison of hospital data with blood pack level information from hospital blood banks.
- Calculation of sensitivity, specificity, and predictive values.
Main Results:
- Data included 235,796 births; 2.0% received transfusions.
- Overall sensitivity of hospital data was 84.8%, specificity 99.9%.
- Sensitivity was higher for postpartum hemorrhage cases (90.9%) and lower in regional hospitals (78.8%).
- 96% of transfusions of 10+ units were identified.
Conclusions:
- Hospital administrative data demonstrates high reliability for reporting red cell transfusions in maternity patients.
- Underreporting is present, particularly in regional settings.
- Data accuracy supports its use for transfusion practice analysis, with awareness of limitations.
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