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Related Experiment Video

Updated: Mar 23, 2026

Development of a Direct Pulp-capping Model for the Evaluation of Pulpal Wound Healing and Reparative Dentin Formation in Mice

Development of a Direct Pulp-capping Model for the Evaluation of Pulpal Wound Healing and Reparative Dentin Formation in Mice

Published on: January 12, 2017

Tertiary Dentin Formation after Indirect Pulp Capping Using Protein CPNE7.

H W Choung¹, D S Lee¹, Ji-Hyun Lee¹

¹Department of Oral Histology/Developmental Biology, School of Dentistry and Dental Research Institute, Seoul National University, Seoul, Republic of Korea.

Journal of Dental Research

|March 26, 2016

Summary

This summary is machine-generated.

Copine7 (CPNE7) protein shows promise as a novel indirect pulp capping (IPC) material. It effectively promotes physiologic reactionary dentin formation and may alleviate dentin hypersensitivity.

Keywords:

biomaterial(s)dentinogenesis development epithelial-mesenchymal interaction mineralized tissue regeneration

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Last Updated: Mar 23, 2026

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Isolation, Characterization and Comparative Differentiation of Human Dental Pulp Stem Cells Derived from Permanent Teeth by Using Two Different Methods

Isolation, Characterization and Comparative Differentiation of Human Dental Pulp Stem Cells Derived from Permanent Teeth by Using Two Different Methods

Published on: November 24, 2012

Area of Science:

Biomaterials Science
Dental Regenerative Medicine
Odontoblast Biology

Background:

Indirect pulp capping (IPC) is crucial for preserving pulp vitality after dentin loss.
Copine7 (CPNE7) has demonstrated potential in inducing odontoblast differentiation and dentin formation.
Current IPC materials like Mineral Trioxide Aggregate (MTA) have limitations in regenerative capacity.

Purpose of the Study:

To evaluate CPNE7 protein as an IPC agent for tertiary dentin formation.
To compare the efficacy of CPNE7 with MTA in a canine indirect pulp capping model.
To assess the effects of CPNE7 on dentinal tubule occlusion and pulp protection.

Main Methods:

An in vivo indirect pulp capping model was established in beagle canine teeth.
CPNE7 protein was applied to exposed dentinal surfaces.
Mineral trioxide aggregate (MTA) was used as a control material.
Scanning electron microscopy (SEM) was employed to analyze dentin structure and tubule occlusion.

Main Results:

CPNE7 promoted the regeneration of physiologic reactionary dentin with intact dentinal tubules.
MTA generated irregular reparative dentin.
The combination of CPNE7 and MTA exhibited synergistic effects, forming reactionary dentin.
SEM analysis revealed occlusion of dentinal tubules by peritubular dentin in CPNE7-treated groups.

Conclusions:

CPNE7 functions as an effective indirect pulp capping material.
CPNE7 promotes the formation of high-quality reactionary dentin, superior to MTA.
CPNE7 has the potential to serve as a novel therapeutic agent for dentin hypersensitivity and pulp protection.