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Rosuvastatin Reduces Blood Viscosity in Patients with Acute Coronary Syndrome

Lae-Young Jung1, Sang-Rok Lee1, Jin-Mu Jung2

  • 1Division of Cardiology, Chonbuk National University Hospital and Chonbuk National University Medical School, Jeonju, Korea.

Korean Circulation Journal
|March 26, 2016
PubMed

Insights

Statins significantly reduce whole blood viscosity (WBV) in acute coronary syndrome (ACS) patients. One month of rosuvastatin treatment lowered WBV in statin-naïve individuals, indicating statins

Area of Science:

  • Cardiovascular Medicine
  • Pharmacology
  • Biophysics

Background:

  • Wall shear stress is implicated in atherosclerosis progression and plaque rupture.
  • Limited research exists on statins' impact on whole blood viscosity (WBV) in acute coronary syndrome (ACS) patients.
  • This study investigates the effect of statin therapy on WBV in ACS patients.

Purpose of the Study:

  • To determine the effect of statin therapy on whole blood viscosity (WBV) in patients with acute coronary syndrome (ACS).
  • To compare WBV between patients with prior statin use and statin-naïve patients.
  • To assess the change in WBV after one month of rosuvastatin treatment in statin-naïve ACS patients.

Main Methods:

  • Prospective enrollment of 189 ACS patients (52 STEMI, 84 NSTEMI, 53 UA).
  • Patients divided into two groups: prior statin users (n=51) and statin-naïve (n=138).
  • Measurement of systolic (SBV) and diastolic blood viscosity (DBV) at baseline and one month post-treatment with rosuvastatin (16.2±4.9 mg/day).

Main Results:

  • Baseline WBV (SBV and DBV) was significantly higher in statin-naïve patients compared to prior statin users (p<0.003).
  • One month of rosuvastatin treatment significantly decreased WBV (SBV and DBV) in statin-naïve patients (p<0.044).
  • Low-density lipoprotein cholesterol levels showed no association with WBV at baseline or follow-up.

Conclusions:

  • Prior statin medication is a significant factor in reducing WBV in ACS patients.
  • Short-term rosuvastatin treatment effectively decreases WBV in statin-naïve ACS patients.
  • Statin therapy demonstrates a beneficial effect on hemorheological properties in ACS.
Abstract

Keywords:
Acute coronary syndromeBlood viscosityRheologyRosuvastatin

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