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Updated: Mar 23, 2026

A Rapid and Specific Microplate Assay for the Determination of Intra- and Extracellular Ascorbate in Cultured Cells
Published on: April 11, 2014
Ascorbic acid serum levels are reduced in patients with hematological malignancies
Mirelle J A J Huijskens1, Will K W H Wodzig2, Mateusz Walczak1
1Department of Internal Medicine, Division of Hematology, Maastricht University Medical Center, Maastricht, The Netherlands.
Abstract:
In this paper we demonstrate that patients treated with chemotherapy and/or hematopoietic stem cell transplantation (HSCT) have highly significant reduced serum ascorbic acid (AA) levels compared to healthy controls. We recently observed in in vitro experiments that growth of both T and NK cells from hematopoietic stem cells is positively influenced by AA. It might be of clinical relevance to study the function and recovery of immune cells after intensive treatment, its correlation to AA serum levels and the possible effect of AA supplementation.
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