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Whole Genome Sequencing of Candida glabrata for Detection of Markers of Antifungal Drug Resistance
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Emerging Threats in Antifungal-Resistant Fungal Pathogens

Dominique Sanglard1

  • 1Institute of Microbiology, University Hospital Center, University of Lausanne , Lausanne , Switzerland.

Frontiers in Medicine
|March 26, 2016
PubMed

Insights

Antifungal drug resistance is a growing concern in treating fungal infections. This review highlights emerging resistance patterns, including environmental sources and multidrug resistance in Candida and Aspergillus species.

Area of Science:

  • Mycology
  • Infectious Diseases
  • Pharmacology

Background:

  • Antifungal drug resistance is a significant challenge in managing fungal infections, affecting treatment efficacy.
  • Mechanisms of resistance, including genetic mutations and specific genes, have been identified in key pathogens like Candida and Aspergillus species.
  • Limited therapeutic options necessitate exploring combination therapies and understanding novel resistance trends.

Purpose of the Study:

  • To review current trends in antifungal resistance.
  • To summarize novel resistance patterns observed in fungal pathogens.
  • To provide an overview of molecular mechanisms underlying antifungal resistance.

Main Methods:

  • Literature review of recent studies on antifungal resistance.
  • Analysis of reported cases of antifungal resistance in Candida and Aspergillus species.
  • Synthesis of information on molecular mechanisms and emerging resistance patterns.

Main Results:

  • Antifungal resistance is prevalent across various antifungal agents and pathogens.
  • Molecular mechanisms, including drug resistance genes and genome mutations, are increasingly understood.
  • Novel resistance patterns include environmental antifungal resistance in Aspergillus fumigatus and multidrug resistance in Candida species.

Conclusions:

  • Understanding emerging antifungal resistance is crucial for effective treatment strategies.
  • Continued research into molecular mechanisms and novel resistance patterns is essential.
  • Addressing antifungal resistance requires a comprehensive approach, including monitoring and development of new therapies.
Keywords:
AspergillusCandidaantifungalsdrug resistance

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