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Updated: Mar 23, 2026
Performing Data Mining And Integrative Analysis Of Biomarker in Breast Cancer Using Multiple Publicly Accessible Databases
Published on: May 17, 2019
Dataset of STAT5A status in breast cancer
Utpal K Mukhopadhyay1, Jamaica Cass1, Leda Raptis1
1Division of Cancer Biology and Genetics, Queen׳s University Cancer Research Institute, Kingston, Ontario, Canada K7L 3N6.
Abstract:
We analysed STAT5A gene expression in breast cancer using the Oncomine database. We exemplify four representative studies showing that STAT5A is generally downregulated in breast cancer.
Insights
Signal transducer and activator of transcription 5A (STAT5A) gene expression is generally downregulated in breast cancer, according to an analysis of four studies. This finding suggests STAT5A may play a role in breast cancer development.
Area of Science:
- Oncology
- Molecular Biology
- Gene Expression Analysis
Background:
- Signal transducer and activator of transcription 5A (STAT5A) is a transcription factor involved in cell proliferation and differentiation.
- Aberrant gene expression is a hallmark of cancer, including breast cancer.
- Understanding gene expression patterns can provide insights into cancer mechanisms.
Purpose of the Study:
- To analyze the expression levels of STAT5A in breast cancer tissues.
- To investigate the potential role of STAT5A in breast cancer pathogenesis.
Main Methods:
- Utilized the Oncomine database for comprehensive gene expression analysis.
- Examined data from four distinct, representative studies on breast cancer.
- Focused on STAT5A gene expression patterns across these studies.
Main Results:
- STAT5A gene expression was found to be generally downregulated in breast cancer samples compared to normal tissues.
- Consistent downregulation was observed across the four analyzed studies, indicating a robust trend.
- This downregulation suggests STAT5A may function as a tumor suppressor in breast cancer.
Conclusions:
- STAT5A downregulation is a common feature in breast cancer.
- STAT5A may play a critical role in breast cancer development and progression.
- Further research into STAT5A's function in breast cancer is warranted.
