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Related Concept Videos

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Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
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Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
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Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
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Related Experiment Video

Updated: Mar 23, 2026

A Proinflammatory, Degenerative Organ Culture Model to Simulate Early-Stage Intervertebral Disc Disease.
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Stem Cells and Discogenic Low Back Pain.

Kee D Kim1

  • 1UC Davis School of Medicine, UC Davis Health System, Sacramento, CA.

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This summary is machine-generated.

Degenerative disc disease (DDD) causes low back pain (LBP), but most patients with disc degeneration are asymptomatic. This lack of correlation between degeneration and pain complicates diagnosis and treatment.

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Area of Science:

  • Orthopedics
  • Pain Management
  • Radiology

Background:

  • Low back pain (LBP) is a common condition often linked to degenerative disc disease (DDD).
  • Significant healthcare resources are allocated to managing LBP associated with DDD.
  • The relationship between the extent of disc degeneration and pain intensity is not well-defined.

Purpose of the Study:

  • To investigate the diagnostic challenges in low back pain (LBP) stemming from degenerative disc disease (DDD).
  • To explore the disconnect between asymptomatic disc degeneration and reported pain levels.

Main Methods:

  • Review of existing literature on degenerative disc disease (DDD) and low back pain (LBP).
  • Analysis of patient data correlating imaging findings of disc degeneration with reported pain severity.

Main Results:

  • The majority of individuals with evidence of disc degeneration do not experience symptomatic pain.
  • A weak or non-existent correlation exists between the degree of disc degeneration observed on imaging and the severity of reported low back pain (LBP).

Conclusions:

  • Diagnostic approaches for low back pain (LBP) require refinement beyond solely relying on imaging evidence of degenerative disc disease (DDD).
  • Further research is needed to understand the multifactorial nature of LBP and develop targeted, effective treatments.