Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Spinal Cord: Information Processing01:10

Spinal Cord: Information Processing

4.2K
The spinal cord is an integral hub for motor and sensory information that enables the brain to communicate with the peripheral nervous system (PNS). This communication consists of relaying sensory data and transmission of motor commands.
Sensory Information Processing
Sensory information processing begins at the sensory receptors located in the skin and other tissues, which detect somatic sensory stimuli such as touch, temperature, or pain. These receptors function as catalysts, initiating...
4.2K
Spinal Cord01:26

Spinal Cord

2.7K
The spinal cord, a critical component of the central nervous system, extends from the base of the brainstem to the lumbar region of the vertebral column. It is essential for maintaining physical stability and facilitating communication between the brain and peripheral parts of the body.
2.7K
Neurogenesis and Regeneration of Nervous Tissue01:15

Neurogenesis and Regeneration of Nervous Tissue

2.0K
In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
2.0K
The Spinal Cord01:54

The Spinal Cord

32.8K
The spinal cord is the body’s major nerve tract of the central nervous system, communicating afferent sensory information from the periphery to the brain and efferent motor information from the brain to the body. The human spinal cord extends from the hole at the base of the skull, or foramen magnum, to the level of the first or second lumbar vertebra.
32.8K
Spinal Cord: Cross-sectional Anatomy01:16

Spinal Cord: Cross-sectional Anatomy

6.0K
The cross-sectional anatomy of the spinal cord offers a detailed view of its complex structure and function within the central nervous system. At the core of the spinal cord lies the gray matter, characterized by its butterfly or "H"-shaped appearance in cross-section. This central region is enveloped by white matter, with the overall structure divided into symmetrical halves by the dorsal median sulcus and the ventral median fissure.
Gray Matter and its Components
Central to the gray matter is...
6.0K
Spinal Cord: Gross Anatomy01:15

Spinal Cord: Gross Anatomy

7.1K
The spinal cord resides within the protective confines of the vertebral column. It is the main pathway for information traveling between the brain and the body. It plays a fundamental role in nearly all bodily functions, from simple reflexes to complex motor movements. The spinal cord begins at the medulla oblongata at the base of the brainstem and extends downward, terminating at the conus medullaris near the first and second lumbar vertebrae. The spinal cord's length in adults is...
7.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Development and Validation of a Prediction Model for Pain and Functional Outcomes After Lumbar Spine Surgery.

JAMA surgery·2018
Same author

Inferior vena cava thrombosis causing acute cauda equina syndrome. Case report.

Journal of neurosurgery·2006
Same author

Aneurysmal bone cyst of the atlas: successful treatment through selective arterial embolization: case report.

Neurosurgery·2005
Same author

Charcot arthropathy in relation to autonomic dysreflexia in spinal cord injury: case report and review of the literature.

Journal of neurosurgery. Spine·2005
Same author

Mechanical failure of the electrode wire in deep brain stimulation.

Parkinsonism & related disorders·2004
Same author

"Plough" fracture: shear fracture of the anterior arch of the atlas.

AJR. American journal of roentgenology·2003

Related Experiment Video

Updated: Mar 23, 2026

An In Vivo Duo-color Method for Imaging Vascular Dynamics Following Contusive Spinal Cord Injury
09:25

An In Vivo Duo-color Method for Imaging Vascular Dynamics Following Contusive Spinal Cord Injury

Published on: December 31, 2017

10.0K

Cellular Events and Pathophysiology of SCI.

A Alex Mohit1

  • 1St. Joseph Medical Center, Tacoma, WA.

Spine
|March 26, 2016
PubMed
Summary

Spinal cord injury (SCI) causes significant neurological damage and cell loss, leading to incomplete spontaneous repair. Understanding SCI

Area of Science:

  • Neuroscience
  • Pathology
  • Regenerative Medicine

Background:

  • Spinal cord injury (SCI) affects millions globally, with 130,000 new cases annually.
  • SCI involves compression, hemorrhage, cell death (neurons, oligodendroglia, astrocytes), and inflammation.
  • Pathological processes include cavitation, Wallerian degeneration, and glial scar formation, leading to neuronal circuitry loss.

Purpose of the Study:

  • To detail the pathological cascade following spinal cord injury.
  • To highlight the limitations of spontaneous repair mechanisms in the spinal cord.
  • To provide a foundation for developing therapeutic strategies for SCI.

Main Methods:

  • Review of pathological processes in spinal cord injury.
  • Analysis of cellular and tissue responses post-injury.

More Related Videos

Neural Stem Cell Transplantation in Experimental Contusive Model of Spinal Cord Injury
10:56

Neural Stem Cell Transplantation in Experimental Contusive Model of Spinal Cord Injury

Published on: December 17, 2014

13.6K
Development of Combinatorial Therapeutics for Spinal Cord Injury using Stem Cell Delivery
05:13

Development of Combinatorial Therapeutics for Spinal Cord Injury using Stem Cell Delivery

Published on: June 7, 2024

561

Related Experiment Videos

Last Updated: Mar 23, 2026

An In Vivo Duo-color Method for Imaging Vascular Dynamics Following Contusive Spinal Cord Injury
09:25

An In Vivo Duo-color Method for Imaging Vascular Dynamics Following Contusive Spinal Cord Injury

Published on: December 31, 2017

10.0K
Neural Stem Cell Transplantation in Experimental Contusive Model of Spinal Cord Injury
10:56

Neural Stem Cell Transplantation in Experimental Contusive Model of Spinal Cord Injury

Published on: December 17, 2014

13.6K
Development of Combinatorial Therapeutics for Spinal Cord Injury using Stem Cell Delivery
05:13

Development of Combinatorial Therapeutics for Spinal Cord Injury using Stem Cell Delivery

Published on: June 7, 2024

561
  • Examination of axonal sprouting and circuit reorganization.

    • Main Results:

    • Necrosis begins within 24 hours post-SCI.
    • Incomplete spontaneous repair involves limited axonal sprouting and bypass circuits.
    • Glial scar formation impedes axonal regeneration perpendicular to the injury site.

    Conclusions:

    • Spinal cord injury results in complex and severe tissue damage.
    • Current spontaneous repair mechanisms are insufficient for functional recovery.
    • Further research is needed to enhance spinal cord repair and regeneration.