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Combined pleomorphic xanthoastrocytoma-ganglioglioma with BRAF V600E mutation: case report
Marta Cicuendez1, Elena Martinez-Saez2, Francisco Martinez-Ricarte3
1Department of Neurosurgery;
Abstract:
Combined pleomorphic xanthoastrocytoma (PXA) and ganglioglioma (GG) is an extremely rare tumor, with fewer than 20 cases reported. The authors report a case of combined PXA-GG in an 18-year-old man with a history of seizures. The tumor showed necrosis and the BRAF V600E mutation on histological examination, with no evidence of tumor recurrence 1 year after gross-total resection. The BRAF V600E mutation was present, which suggests that both cell lineages may share a common cellular origin.
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