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Updated: Mar 23, 2026
Detection of Functional Matrix Metalloproteinases by Zymography
Published on: November 8, 2010
Serum matrix metalloproteinase-2: A potential biomarker for diagnosis of epilepsy
Rui Wang1, Guang Qun Zeng2, Rui Zhan Tong3
1Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan, People's Republic of China.
Objectives:
In this study, we evaluate the utility of serum metalloproteinase-2 (MMP-2) as a biomarker for the diagnosis of epilepsy.
Methods:
We assessed serum MMP-2 levels in 233 epileptic and 97 healthy control subjects. Control subjects had no complaints or signs of neurological disorders for at least 12 months prior to serum collection. Serum MMP-2 levels were determined using the Luminex technology.
Results:
Compared with controls, subjects with epilepsy had significantly lower serum MMP-2 concentrations (P<0.05). There was no significant difference between males and females in either group (P>0.05). Serum MMP-2 concentrations were highly correlated with age in both groups, and this correlation was strongest for males. When an MMP-2 cut-off value of 175.40ng/ml was used, the sensitivity for distinguishing subjects with epilepsy from controls was 71.13% and the specificity was 62.66%.
Conclusions:
Our results reveal that serum MMP-2 may be a potential biomarker for the diagnosis of epilepsy.
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