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Assessment of oxidative stress and inflammation in prediabetes-A hospital based cross-sectional study

Ashish Agarwal1, Anupama Hegde1, Charu Yadav1

  • 1Department of Biochemistry, Kasturba Medical College, Manipal University, ,Mangalore 575004, Karnataka, India.

Diabetes & Metabolic Syndrome
|March 28, 2016
PubMed

Insights

Prediabetes increases cardiovascular disease risk through inflammation and oxidative stress. Elevated markers like interleukin-6 and myeloperoxidase correlate with central obesity in prediabetic individuals.

Area of Science:

  • Endocrinology and Metabolism
  • Cardiovascular Research
  • Biochemistry

Background:

  • Prediabetes is linked to metabolic dysfunction, including dysglycemia, obesity, inflammation, and endothelial dysfunction.
  • These factors contribute to the pathogenesis of cardiovascular diseases (CVD), increasing vulnerability in prediabetic individuals.

Purpose of the Study:

  • To investigate the association between prediabetes and cardiovascular disease (CVD) risk.
  • To assess oxidative stress and inflammation markers: serum interleukin-6 (IL-6), myeloperoxidase (MPO), and urine microalbumin (MA).
  • To explore correlations between these markers, fasting plasma glucose (FPG), and physical measurements.

Main Methods:

  • Eighty subjects were categorized into prediabetes and healthy control groups based on FPG levels.
  • Serum IL-6 and MPO levels were measured.
  • Urine MA levels were assessed in random urine samples.

Main Results:

  • The prediabetes group exhibited significantly higher mean anthropometric measurements, IL-6, MPO, and MA compared to healthy controls (p<0.05).
  • MPO showed a significant correlation with FPG (r=0.388) in the prediabetes group.
  • IL-6 and MPO positively correlated with body mass index (BMI), waist circumference (WC), and waist-to-hip ratio (WHR). MA did not correlate with FPG or anthropometric measurements.

Conclusions:

  • Prediabetes is associated with central adiposity, inflammation, and oxidative stress.
  • These findings suggest prediabetes predisposes individuals to an increased risk of cardiovascular disease (CVD).
Abstract

Keywords:
Interleukin-6 (IL-6)Microalbuminuria (MA)Myeloperoxidase (MPO)Prediabetes

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