Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Introduction to the Human Microbiota01:22

Introduction to the Human Microbiota

29
Microorganisms colonize various regions of the human body, including the mouth, nasal passages, throat, stomach, intestines, urogenital tract, and skin. The total number of microbial cells is estimated to range from 10¹³ to 10¹⁴—comparable to, or exceeding, the number of human somatic cells. This host–microbiome relationship has led to the conceptualization of humans as supraorganisms, wherein microbial communities perform vital roles in development, immunity,...
29
Development of Human Microbiota01:30

Development of Human Microbiota

11
The human microbiota begins developing at birth and undergoes continual change as we age. Infancy marks a critical period of microbial sensitivity, offering a “window of opportunity” during which beneficial microbes help mature the immune system. By age three, children typically develop a more stable and diverse microbial community. Newborns acquire microbes from their immediate environment; vaginal delivery favors maternal vaginal microbes, while cesarean births favor microbes from...
11
Microorganisms in Medicine and Therapeutics01:29

Microorganisms in Medicine and Therapeutics

1.3K
Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
1.3K
Functions of the Gut Microbiota01:18

Functions of the Gut Microbiota

5
The gut microbiota includes trillions of microorganisms that colonize the human gastrointestinal tract, including bacteria, archaea, viruses, and fungi. This complex ecosystem plays a critical role in maintaining intestinal and systemic health. Most of these microbes inhabit the large intestine, establishing a relatively stable and diverse community that contributes to gut homeostasis through various metabolic, immunological, and protective mechanisms.Dominant bacterial phyla, such as...
5
Human Virome01:26

Human Virome

27
The human body harbors a vast and diverse viral community known as the human virome. The virome includes bacteriophages that infect bacteria, and eukaryotic viruses that infect human cells. Transient dietary and environmental viruses also contribute to this dynamic ecosystem. Estimates suggest the human body may contain on the order of 10¹³ viral particles, though abundance varies widely by body site and detection method.Comprehensive characterization of the virome has become possible...
27
Probiotics01:22

Probiotics

50
Probiotics are live, non-pathogenic microorganisms that confer health benefits by modulating the gut microbiota. The human gastrointestinal tract harbors a complex microbial ecosystem, and the balance of this microbiota is crucial for digestive and systemic health. Among the most extensively studied and utilized probiotics are species formerly classified within the genera Lactobacillus and Bifidobacterium. These organisms not only naturally colonize the human gut but are also consumed through...
50

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Corrigendum to "Harmful effects of true-to-life nanoplastics derived from PET water bottles in human alveolar macrophages" [Environ. Pollut., 348: 123823 (2024)].

Environmental pollution (Barking, Essex : 1987)·2024
Same author

Uniaxial pressure control of competing orders in a high-temperature superconductor.

Science (New York, N.Y.)·2018
Same author

Detection of peripheral embolic consolidations using contrast-enhanced ultrasonography in patients with no evidence of pulmonary embolism on computed tomography: A pilot study.

Journal of clinical ultrasound : JCU·2017
Same author

Urticaria caused by ingestion of pasta and bread containing buckwheat flour.

Journal of investigational allergology & clinical immunology·2013
Same author

Influence of DNA-repair gene variants on the micronucleus frequency in thyroid cancer patients.

Mutation research·2012
Same author

Measurement of the proton-air cross section at √s=57 TeV with the Pierre Auger Observatory.

Physical review letters·2012

Related Experiment Video

Updated: Mar 23, 2026

Therapeutic Evaluation of Fecal Microbiota Transplantation in an Interleukin 10-Deficient Mouse Model
05:41

Therapeutic Evaluation of Fecal Microbiota Transplantation in an Interleukin 10-Deficient Mouse Model

Published on: April 6, 2022

3.6K

Engineering Human Microbiota: Influencing Cellular and Community Dynamics for Therapeutic Applications.

S Woloszynek1, S Pastor2, J C Mell3

  • 1Department of Electrical and Computer Engineering, Drexel University, Philadelphia, PA, United States of America.

International Review of Cell and Molecular Biology
|March 28, 2016
PubMed
Summary

Understanding the human microbiome is key, as researchers explore how microbial communities interact with our bodies. This study details strategies for engineering the microbiome to restore balance in unstable microbial ecosystems, like dysbiosis.

Keywords:
human microbiomemetabolic cross-feedingmicrobiota transplantationprebioticsprobioticsquorum sensingsynthetic consortia

More Related Videos

Analysis of Interactions between Endobiotics and Human Gut Microbiota Using In Vitro Bath Fermentation Systems
06:58

Analysis of Interactions between Endobiotics and Human Gut Microbiota Using In Vitro Bath Fermentation Systems

Published on: August 23, 2019

7.7K
A Double Humanized BLT-mice Model Featuring a Stable Human-Like Gut Microbiome and Human Immune System
07:32

A Double Humanized BLT-mice Model Featuring a Stable Human-Like Gut Microbiome and Human Immune System

Published on: August 30, 2019

9.4K

Related Experiment Videos

Last Updated: Mar 23, 2026

Therapeutic Evaluation of Fecal Microbiota Transplantation in an Interleukin 10-Deficient Mouse Model
05:41

Therapeutic Evaluation of Fecal Microbiota Transplantation in an Interleukin 10-Deficient Mouse Model

Published on: April 6, 2022

3.6K
Analysis of Interactions between Endobiotics and Human Gut Microbiota Using In Vitro Bath Fermentation Systems
06:58

Analysis of Interactions between Endobiotics and Human Gut Microbiota Using In Vitro Bath Fermentation Systems

Published on: August 23, 2019

7.7K
A Double Humanized BLT-mice Model Featuring a Stable Human-Like Gut Microbiome and Human Immune System
07:32

A Double Humanized BLT-mice Model Featuring a Stable Human-Like Gut Microbiome and Human Immune System

Published on: August 30, 2019

9.4K

Area of Science:

  • Microbiology and Human Physiology
  • Microbiome Research
  • Environmental Health

Background:

  • The human microbiome's role in health and disease is a growing research area.
  • High-throughput sequencing has advanced microbiome studies, revealing complex host-microbe interactions.
  • Early research relied on correlative data, highlighting the need for experimental approaches.

Purpose of the Study:

  • To explore the intricate interplay between microbiota and host physiology.
  • To detail strategies for manipulating and engineering the microbiome.
  • To address the challenge of unstable microbial communities (dysbiosis).

Main Methods:

  • Review of current research on microbiome engineering.
  • Analysis of strategies for reestablishing microbial community stability.
  • Discussion of techniques including intermicrobial communication, designer probiotics, fecal microbiota transplantation, and synthetic biology.

Main Results:

  • The study highlights the transition from correlative to experimental microbiome research.
  • It emphasizes the potential of microbiome engineering to address health issues.
  • Key strategies for restoring microbial balance are presented.

Conclusions:

  • Microbiome engineering offers promising avenues for therapeutic interventions.
  • Understanding and manipulating host-microbe interactions is crucial for health.
  • Restoring microbial ecosystem stability is a primary goal in microbiome research.