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Related Concept Videos

Teeth01:15

Teeth

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The formation of teeth, also known as odontogenesis, is a complex process that begins in utero, around the sixth week of embryonic development. There are three stages to this process: the bud stage, the cap stage, and the bell stage.
In the bud stage, the tooth germ (an aggregation of cells) starts to form in the developing jawbone. During the cap stage, the tooth germ differentiates into enamel organ, dental papilla, and dental sac, which will later develop into the tooth's enamel, dentin...
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Overview of Regeneration and Repair01:19

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Regeneration and repair processes are critical in healing damages caused by injury, disease, and aging. In regeneration, the damaged tissue is entirely replaced with new growth that restores the original architecture and function. In contrast, tissue repair usually results in a fixed tissue architecture involving scar formation. Scars generally do not reestablish tissue function and may also exhibit structural abnormalities at the injury site.
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Tooth Anatomy01:21

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The human tooth enables us to eat a variety of foods, speak clearly, and even aid in shaping our faces. Teeth are composed of various elements that work together. Here's a detailed look at the anatomy of a human tooth.
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Tissue Renewal without Stem Cells01:23

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After cellular or tissue damage, the resident stem cells present in the human body can locally repair and regenerate the damaged tissue or organ. However, even though some tissues do not have stem cells, they can repair and regenerate with the help of pre-existing cells. For example, beta cells of the pancreas and hepatocytes of the liver can divide to renew and regenerate the tissue. Here, both cell division and cell death are well regulated by homeostasis.
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Stem Cell Therapy for Tissue Regeneration01:21

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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
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Guided Endodontics: Three-Dimensional Planning and Template-Aided Preparation of Endodontic Access Cavities
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Regenerative endodontics: A way forward.

Anibal Diogenes, Nikita B Ruparel, Yoav Shiloah

    Journal of the American Dental Association (1939)
    |March 28, 2016
    PubMed
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    Regenerative endodontic procedures (REPs) offer a promising alternative for immature teeth with pulpal necrosis, promoting root development and healing. While not true regeneration, REPs provide a guided repair process for better outcomes.

    Keywords:
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    Area of Science:

    • Endodontics
    • Regenerative medicine
    • Dental traumatology

    Background:

    • Immature teeth face infection risks from trauma, anomalies, and caries.
    • Traditional apexification fails to promote root development, increasing fracture risk.
    • Regenerative endodontic procedures (REPs) are a viable alternative for immature teeth.

    Purpose of the Study:

    • To summarize the current status of regenerative endodontics.
    • To provide insight into expected clinical outcomes of REPs.
    • To evaluate REPs as a treatment for immature teeth with pulpal necrosis.

    Main Methods:

    • Review of published studies on regenerative endodontics.
    • Analysis of factors influencing stem cell-mediated regeneration.
    • Assessment of clinical outcomes and radiographic development.

    Main Results:

    • REPs promote healing of apical periodontitis and continued root development.
    • Vitality responses are observed in some cases following REPs.
    • REPs facilitate a guided endodontic repair rather than complete tissue regeneration.

    Conclusions:

    • REPs are a viable first-line treatment for immature teeth with pulpal necrosis.
    • These procedures can be followed by apexification if unsuccessful.
    • Advances in regenerative endodontics enhance understanding of pulp-dentin complex repair.