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High-sensitivity cardiac troponin T in geriatric inpatients

Shao-Jing Zhang1, Qing Wang1, Yun-Jing Cui1

  • 1Department of Geriatrics, Fuxing Hospital Affiliated to Capital Medical University, Beijing, China.

Archives of Gerontology and Geriatrics
|March 28, 2016
PubMed

Insights

High-sensitivity cardiac troponin T (hs-cTnT) is commonly detected in elderly patients, even without cardiovascular disease. Elevated hs-cTnT levels are linked to increased cardiovascular risks and are influenced by factors like age and kidney function.

Area of Science:

  • Cardiology
  • Geriatrics
  • Biomarkers

Background:

  • High-sensitivity cardiac troponin T (hs-cTnT) is frequently detectable in elderly individuals without diagnosed cardiovascular disease.
  • Elevated hs-cTnT levels in this population are associated with heightened cardiovascular risks and poorer prognosis.

Purpose of the Study:

  • To investigate the distribution of hs-cTnT levels in geriatric inpatients without acute coronary syndrome (ACS).
  • To identify factors associated with hs-cTnT levels in this specific patient group.

Main Methods:

  • Hs-cTnT was measured using a sensitive assay in 679 geriatric inpatients without ACS.
  • Patients were stratified into tertiles based on hs-cTnT levels.
  • Univariable and multivariable analyses assessed associations with cardiovascular risk factors, biochemical markers, and echocardiographic findings.

Main Results:

  • Hs-cTnT was detectable (≥3 ng/L) in 98.4% of subjects; 52.0% had levels ≥14 ng/L (99th percentile URL).
  • Independent predictors of hs-cTnT included NT-proBNP, male gender, older age, eGFR, LVMI, DM, and LVEF.
  • No significant difference in hs-cTnT levels was observed between patients with and without stable coronary artery disease (SCAD).

Conclusions:

  • Elevated hs-cTnT due to non-ischemic causes is common in hospitalized elderly patients.
  • Assessing hs-cTnT level changes (rise/fall) is crucial for diagnosing ACS/AMI in the elderly, considering elevated baseline levels.
  • Further research is needed to establish age-specific 99th percentile values for hs-cTnT in the elderly.
Abstract

Keywords:
ACSGeriatric inpatientsHigh-sensitivity cardiac troponin TRelated factors

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