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Updated: Mar 23, 2026

Visualizing Scar Development Using SCAD Assay - An Ex-situ Skin Scarring Assay
Published on: April 28, 2022
Different cutaneous innate immunity profiles in acne patients with and without atrophic scars
Mélanie Saint-Jean1, Amir Khammari1, Fiona Jasson2
1Dermato-Oncology department, Nantes Hospital, 1 place Alexis Ricordeau, 44093 Nantes, France, CRCNA, Inserm U892, CNRS 6299, 9 quai Moncousu, 44093 Nantes cedex 1, France.
Background:
Acne is a chronic inflammatory disease associated with scar development in many patients.
Objectives:
To check whether early inflammatory events in the epidermis via keratinocytes influence the development of scars in acne patients.
Methods:
We investigated several immunological markers involved in epidermal innate immunity in both clinically normal skin and inflammatory early papules in acne patients prone to scars or not.
Results:
In normal skin of acne patients prone to scars vs not prone to scars, TLR-4, IL-2, IL-10, TIMP-2 and JUN were significantly overexpressed and the MMP-9 protein level was decreased. Similar results were obtained in early inflammatory papules (no more than three days), except for TLR-4.
Conclusion:
These results suggest for the first time a link between the early events of inflammation with levels of activation of innate immunity in normal epidermis of acne patients and the development of scars. These markers could be a target for drugs in the field of scar prevention.
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