Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Overview of Exosomes

Overview of Exosomes

Exosomes are stable, lipid bilayer-enclosed vesicles capable of crossing biological barriers. They can carry a wide range of molecules required for intercellular communication. Once exosomes are released from the cell where they originated, they enter a recipient cell through various pathways such as fusion, receptor-mediated endocytosis, macropinocytosis, and phagocytosis.
Stahl et al. discovered exosomes in 1983, but the exosomes were initially considered waste products released from the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Different Functions of Human Scavenger Receptors BI and BII Overexpressed in a Murine Abdominal Sepsis Model.

Biomolecules·2026

Same author

Allograft and recipient tissue injury during cardiac allograft rejection: Evidence from cell-free DNA.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2026

Same author

Different functions of human scavenger receptors BI and BII overexpressed in a murine abdominal sepsis model.

bioRxiv : the preprint server for biology·2026

Same author

Peritoneal neutrophil extracellular traps contribute to septic AKI via peritoneal IL-17A and distant organ CXCL-1/ CXCL-2 pathway in abdominal sepsis.

Scientific reports·2026

Same author

NK cell allorecognition shapes reprogramming of neutrophils infiltrating heart allografts.

bioRxiv : the preprint server for biology·2025

Same author

Peritoneal Neutrophil Extracellular Traps contribute to septic AKI via peritoneal IL-17A and distant organ CXCL-1/ CXCL-2 pathway in abdominal sepsis.

Research square·2025

Same journal

Mt1-Ca<sup>2+</sup>-Mitochondrial Metabolic Axis Maintains Temporomandibular Joint Condylar Cartilage Homeostasis Under Low Oxygen and Hypoxic Condition.

Journal of cellular physiology·2026

Same journal

Correction to "IRE1α/NOX4 Signaling Pathway Mediates Ros-Dependent Activation of Hepatic Stellate Cells in NaAsO<sub>2</sub>-Induced Liver Fibrosis".

Journal of cellular physiology·2026

Same journal

Lipocalin-2 Restores Mitochondrial and Antioxidant Adaptation in a Strain-Specific Manner During LPS Induced Sepsis.

Journal of cellular physiology·2026

Same journal

Dysregulation of Non-Muscle Myosin IIA Assembly and Phosphorylation in S100A4 Null Mouse Lens.

Journal of cellular physiology·2026

Same journal

Corrigendum to "A Probiotic Combination of Limosilactobacillus reuteri and Clostridium butyricum Ameliorates 5-Fluorouracil-Induced Intestinal Mucositis in Rats by Strengthening Barrier Integrity and Modulating Immuno-Microbial Homeostasis".

Journal of cellular physiology·2026

Same journal

Sexually Dimorphic Regulation of MiR-29a/c-3p in Human Endothelial Cells: Cell Functions and Transcriptome.

Journal of cellular physiology·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Mar 23, 2026

An Innovative Method for Exosome Quantification and Size Measurement

An Innovative Method for Exosome Quantification and Size Measurement

Published on: January 17, 2015

Quantification of Exosomes.

Erik H Koritzinsky¹, Jonathan M Street¹, Robert A Star¹

¹Renal Diagnostics and Therapeutics Unit, NIDDK, NIH, Bethesda, Maryland.

Journal of Cellular Physiology

|March 29, 2016

Summary

This summary is machine-generated.

Accurate exosome quantification is crucial for understanding cell biology and interpreting biomarker signals. Developing standardized methods and comparative studies is essential for reliable exosome research.

More Related Videos

Using Nanoplasmon-Enhanced Scattering and Low-Magnification Microscope Imaging to Quantify Tumor-Derived Exosomes

Using Nanoplasmon-Enhanced Scattering and Low-Magnification Microscope Imaging to Quantify Tumor-Derived Exosomes

Published on: May 24, 2019

Nanoparticle Tracking Analysis for the Quantification and Size Determination of Extracellular Vesicles

Nanoparticle Tracking Analysis for the Quantification and Size Determination of Extracellular Vesicles

Published on: March 28, 2021

Related Experiment Videos

Last Updated: Mar 23, 2026

An Innovative Method for Exosome Quantification and Size Measurement

An Innovative Method for Exosome Quantification and Size Measurement

Published on: January 17, 2015

Using Nanoplasmon-Enhanced Scattering and Low-Magnification Microscope Imaging to Quantify Tumor-Derived Exosomes

Using Nanoplasmon-Enhanced Scattering and Low-Magnification Microscope Imaging to Quantify Tumor-Derived Exosomes

Published on: May 24, 2019

Nanoparticle Tracking Analysis for the Quantification and Size Determination of Extracellular Vesicles

Nanoparticle Tracking Analysis for the Quantification and Size Determination of Extracellular Vesicles

Published on: March 28, 2021

Area of Science:

Cell Biology
Biochemistry
Biotechnology

Background:

Exosomes are vesicles released by cells, containing biomolecules that reflect parent cell physiology.
Exosomes are recognized as valuable sources of potential biomarkers for various diseases.
Current research faces challenges due to a lack of standardized exosome quantification methods.

Purpose of the Study:

To highlight the critical need for accurate exosome quantification.
To address the challenges posed by the proliferation of non-standardized quantification techniques.
To propose a path towards more coherent and comparable exosome research.

Main Methods:

Review of current exosome quantification techniques.
Analysis of the limitations and inconsistencies in existing methods.
Discussion of the requirements for developing standardized protocols.

Main Results:

The number of exosome quantification methods has increased significantly.
A lack of consensus on proper quantification hinders inter-study comparability.
Standardized, well-characterized reference materials are needed.

Conclusions:

Standardization of exosome quantification is essential for advancing the field.
Comparative studies across different platforms are necessary.
Developing coherent technical approaches will improve the reliability of exosome-based research and biomarker discovery.