Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Master Transcription Regulators02:23

Master Transcription Regulators

8.0K
Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a  complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...
8.0K
Master Transcription Regulators02:23

Master Transcription Regulators

2.9K
2.9K
Cellular Differentiation00:57

Cellular Differentiation

6.2K
How does a complex organism such as a human develop from a single cell? It all starts from a single fertilized egg which gives rise to a vast array of cell types, such as nerve cells, muscle cells, and epithelial cells that characterize the adult? Throughout development and adulthood, cellular differentiation leads cells to assume their final morphology and physiology. Differentiation is the process by which unspecialized cells become specialized to carry out distinct functions.
A zygote is a...
6.2K
TGF - β Signaling Pathway01:16

TGF - β Signaling Pathway

10.9K
The TGF-β signaling pathway regulates cell growth, differentiation, adhesion, motility, and development. TGF-β ligands that induce TGF-β signaling are synthesized in their latent form. Several proteases or cell surface receptors such as integrins act upon the latent form, releasing the active ligand. There are three types of mammalian TGF-βs: (TGF-β1, TGF-β2, and TGF-β3) that bind as homodimers or heterodimers to TGF-β receptors. The TGF-β receptors...
10.9K
iPS Cell Differentiation01:22

iPS Cell Differentiation

3.3K
The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
3.3K
Differentiation of Common Myeloid Progenitor Cells01:15

Differentiation of Common Myeloid Progenitor Cells

4.2K
Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...
4.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Psoriatic arthritis and obesity: a review of clinical burden and considerations for comprehensive care.

RMD open·2026
Same author

Synovial Telocytes are Characterized by Efhd1, Dpp4, and Pi16 Expression, Show High Responsiveness to Osmotic Stress, and Exhibit Fibroblast Plasticity Potential.

Arthritis & rheumatology (Hoboken, N.J.)·2026
Same author

Effects of Guselkumab on Structural Damage Progression in Patients with Active Psoriatic Arthritis.

Advances in therapy·2026
Same author

Combination Therapy in Participants With Active Psoriatic Arthritis Using Subcutaneous Guselkumab and Golimumab: Week 24 Results From a Phase 2a, Multicenter, Randomized, Double-Blind, Proof-of-Concept Study.

Arthritis & rheumatology (Hoboken, N.J.)·2026
Same author

Telocyte Deletion Associated With Loss of Lymphatic Drainage and Exacerbation of Inflammatory-Erosive Arthritis in Mice.

Arthritis & rheumatology (Hoboken, N.J.)·2026
Same author

Bimekizumab safety and efficacy in patients with psoriatic arthritis: 3-year results from two phase 3 studies.

Rheumatology (Oxford, England)·2026

Related Experiment Video

Updated: Mar 23, 2026

Differentiation and Characterization of Osteoclasts from Human Induced Pluripotent Stem Cells
10:52

Differentiation and Characterization of Osteoclasts from Human Induced Pluripotent Stem Cells

Published on: March 22, 2024

2.4K

DC-STAMP: A Key Regulator in Osteoclast Differentiation.

Ya-Hui Chiu1, Christopher T Ritchlin1

  • 1Division of Allergy, Immunology and Rheumatology, School of Medicine, University of Rochester, Rochester, New York.

Journal of Cellular Physiology
|March 29, 2016
PubMed
Summary

Osteoimmunology reveals bone

Area of Science:

  • Osteoimmunology: the study of bone and immune system interactions.
  • Focus on the role of dendritic cell-specific transmembrane protein (DC-STAMP).

Background:

  • Bone homeostasis relies on balanced osteoblast and osteoclast activity.
  • Imbalances lead to diseases like osteoporosis and osteopetrosis.
  • DC-STAMP is a key regulator of osteoclast differentiation.

Purpose of the Study:

  • To review current knowledge on DC-STAMP.
  • To explore DC-STAMP's role in bone homeostasis and immune regulation.
  • To discuss potential therapeutic applications.

Main Methods:

  • Review of existing literature on DC-STAMP.
  • Analysis of DC-STAMP's interactions and regulatory functions.
  • Exploration of signaling pathways involving DC-STAMP.

More Related Videos

Differentiation of Functional Osteoclasts from Human Peripheral Blood CD14+ Monocytes
11:52

Differentiation of Functional Osteoclasts from Human Peripheral Blood CD14+ Monocytes

Published on: January 27, 2023

4.8K
Stimulation of Notch Signaling in Mouse Osteoclast Precursors
08:01

Stimulation of Notch Signaling in Mouse Osteoclast Precursors

Published on: February 28, 2017

8.4K

Related Experiment Videos

Last Updated: Mar 23, 2026

Differentiation and Characterization of Osteoclasts from Human Induced Pluripotent Stem Cells
10:52

Differentiation and Characterization of Osteoclasts from Human Induced Pluripotent Stem Cells

Published on: March 22, 2024

2.4K
Differentiation of Functional Osteoclasts from Human Peripheral Blood CD14+ Monocytes
11:52

Differentiation of Functional Osteoclasts from Human Peripheral Blood CD14+ Monocytes

Published on: January 27, 2023

4.8K
Stimulation of Notch Signaling in Mouse Osteoclast Precursors
08:01

Stimulation of Notch Signaling in Mouse Osteoclast Precursors

Published on: February 28, 2017

8.4K

Main Results:

  • DC-STAMP regulates both osteoclast and osteoblast differentiation.
  • Elevated DC-STAMP+ cells are linked to psoriatic disease pathogenesis.
  • DC-STAMP interacts with proteins and regulates genes in osteoclastogenesis.

Conclusions:

  • DC-STAMP is crucial for bone homeostasis and immune regulation.
  • DC-STAMP presents a potential therapeutic target for bone diseases and psoriatic conditions.
  • Further research into DC-STAMP's signaling pathways is warranted.