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Related Concept Videos

Drug Delivery: Miscellaneous Routes01:22

Drug Delivery: Miscellaneous Routes

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Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
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Drug Delivery: Parenteral Route01:29

Drug Delivery: Parenteral Route

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The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
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Chemotherapy-Induced Nausea and Vomiting: 5-HT3 Receptor Antagonists01:27

Chemotherapy-Induced Nausea and Vomiting: 5-HT3 Receptor Antagonists

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5-HT3 receptor antagonists, such as dolasetron, granisetron (Kytril), ondansetron (Zofran), and palonosetron (Axoli), are crucial in managing chemotherapy-induced nausea and vomiting (CINV) and postoperative nausea. These drugs selectively block 5-HT3 receptors in the visceral vagal and spinal afferent nerves, chemoreceptor trigger zone, and the vomiting center. They have a rapid onset of action and can be given as a single dose before chemotherapy. Ondansetron and granisetron, in particular,...
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Routes of Drug Administration: Parenteral01:25

Routes of Drug Administration: Parenteral

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The administration of drugs via parenteral routes allows for direct drug introduction into the systemic circulation, resulting in high bioavailability because the medication bypasses the harsh conditions of the gastrointestinal tract and hepatic metabolism.
The intravenous route (IV) of drug administration can be further categorized into two types. The bolus injection administers the entire dose rapidly, while an intravenous infusion slowly delivers smaller doses steadily.
The IV route is often...
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Parenteral Drug Delivery Systems: Injectables, Implants, and Infusion Devices01:28

Parenteral Drug Delivery Systems: Injectables, Implants, and Infusion Devices

108
Parenteral drug delivery systems play a crucial role in modern therapeutics by enabling the direct administration of drugs into the systemic circulation, bypassing the gastrointestinal tract. These systems are particularly valuable for poorly absorbed oral medications that are unstable in the digestive environment or require rapid onset or sustained therapeutic levels. Delivery is achieved through intravenous, intramuscular, or subcutaneous routes, each selected based on the drug's properties...
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Intrauterine Drug Delivery Systems01:21

Intrauterine Drug Delivery Systems

123
Controlled-release systems for intravaginal and intrauterine drug delivery have been developed primarily for the administration of contraceptive steroid hormones. These delivery routes circumvent first-pass hepatic metabolism, thereby enhancing bioavailability and allowing for reduced systemic dosages compared to oral administration. Such approaches contribute to improved therapeutic efficacy and patient compliance, particularly in long-term contraceptive regimens.Intravaginal Drug Delivery...
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Related Experiment Video

Updated: Mar 23, 2026

Endobronchial Ultrasound-guided Intratumoral Injection of Cisplatin for the Treatment of Isolated Mediastinal Recurrence of Lung Cancer
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Endobronchial Ultrasound-guided Intratumoral Injection of Cisplatin for the Treatment of Isolated Mediastinal Recurrence of Lung Cancer

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Current Strategy for Cisplatin Delivery.

Zhanguo Yue, Zhiqiang Cao1

  • 1Department of Chemical Engineering and Materials Science, Wayne State University, Detroit, USA. zcao@wayne.edu.

Current Cancer Drug Targets
|March 29, 2016
PubMed
Summary
This summary is machine-generated.

New cisplatin formulations aim to reduce side effects and overcome drug resistance in cancer chemotherapy. This review covers direct, prodrug, and combination delivery strategies for improved anti-cancer efficiency.

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Evaluating the Effectiveness of Cancer Drug Sensitization In Vitro and In Vivo
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Endobronchial Ultrasound-guided Intratumoral Injection of Cisplatin for the Treatment of Isolated Mediastinal Recurrence of Lung Cancer
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Custom-designed Laser-based Heating Apparatus for Triggered Release of Cisplatin from Thermosensitive Liposomes with Magnetic Resonance Image Guidance
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Evaluating the Effectiveness of Cancer Drug Sensitization In Vitro and In Vivo
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Evaluating the Effectiveness of Cancer Drug Sensitization In Vitro and In Vivo

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Area of Science:

  • Oncology
  • Pharmacology
  • Drug Delivery Systems

Background:

  • Cisplatin is a cornerstone chemotherapy agent with significant clinical utility.
  • Severe side effects and acquired tumor resistance limit cisplatin's efficacy.
  • Novel formulations are crucial to enhance therapeutic outcomes and patient tolerance.

Purpose of the Study:

  • To review recent advancements in cisplatin delivery strategies.
  • To identify challenges in developing improved cisplatin formulations.
  • To discuss potential solutions for overcoming formulation hurdles.

Main Methods:

  • Literature review of recent progress in cisplatin delivery.
  • Analysis of direct, prodrug, and combination delivery approaches.
  • Identification and discussion of key developmental challenges and solutions.

Main Results:

  • Various cisplatin delivery strategies are being explored to mitigate toxicity.
  • Prodrug and combination delivery show promise in enhancing anti-cancer effects.
  • Overcoming formulation challenges is key to clinical translation.

Conclusions:

  • Advanced cisplatin formulations offer a promising avenue to improve cancer treatment.
  • Addressing drug resistance and side effects requires innovative delivery systems.
  • Further research into optimized cisplatin delivery is warranted for clinical application.