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Published on: January 7, 2018
The clinical and biochemical characteristics associated with insulin resistance in non-obese young women
Ching-Chiung Wang1, Chun-Jen Chang2, Ming-I Hsu3,4
1a School of Pharmacy, College of Pharmacy, Taipei Medical University , Taipei , Taiwan.
Aim:
The aim of this study was to investigate the biomarkers of insulin resistance in non-obese women.
Design:
This was a retrospective study.
Patients:
A total 229 non-obese women (Body mass index: BMI < 25) were evaluated.
Main Outcome Measure(S):
Serum levels of various androgens, cardiovascular risk and metabolic components.
Results:
There were no significant differences in the prevalence of polycystic ovary syndrome (PCOS), hyperprolactinemia, or premature ovarian failure (POF) between the non-obese women with and without insulin resistance. Non-obese women with insulin had significantly higher serum thyroid stimulation hormone (TSH) levels and resistin and lower serum adiponectin levels than non-obese women without insulin resistance; however, the inflammatory biomarkers and serum androgen levels did not differ between the two groups. Furthermore, using step-wise multivariate regression analysis applied by the risk factors listed above, TSH was the only predictive factor for insulin resistance in non-obese reproductive-aged women.
Conclusions:
Thyroid function should play an important role in developing insulin resistance for non-obese women. Serum androgens and inflammation might not contribute to insulin resistance in these women.
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