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Sfrp5 associates with beta-cell function in humans.

Maren Carstensen-Kirberg1,2, Erifili Hatziagelaki3, Anastasia Tsiavou3

  • 1Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Düsseldorf, Germany.

European Journal of Clinical Investigation
|March 29, 2016
PubMed
Summary
This summary is machine-generated.

Secreted frizzled-related protein 5 (Sfrp5) is linked to impaired insulin secretion in humans, independent of nonalcoholic fatty liver disease severity. Its association with insulin sensitivity is partially explained by body mass.

Keywords:
Beta-cell functionSfrp5insulin sensitivitynonalcoholic fatty liver diseases

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Area of Science:

  • Metabolic research
  • Endocrinology
  • Human physiology

Background:

  • Secreted frizzled-related protein 5 (Sfrp5) is known to affect insulin sensitivity and beta-cell function in rodents.
  • The role of Sfrp5 in human insulin sensitivity and secretion remains unclear.
  • Nonalcoholic fatty liver disease (NAFLD) is a common metabolic disorder associated with insulin resistance.

Purpose of the Study:

  • To investigate the association between serum Sfrp5 levels and indices of insulin sensitivity and beta-cell function in humans.
  • To explore the relationship using dynamic measurements from oral glucose tolerance tests (OGTT).

Main Methods:

  • Enrolled 194 individuals with NAFLD diagnosed via ultrasound and liver enzymes.
  • Conducted frequent sampling 75-g oral glucose tolerance tests (OGTT).
  • Measured fasting serum Sfrp5 using ELISA and assessed associations with insulin sensitivity and beta-cell function indices.

Main Results:

  • Serum Sfrp5 showed an inverse association with the C-peptide-based insulinogenic index (P=0.001), indicating impaired beta-cell function.
  • Sfrp5 inversely correlated with QUICKI, a marker of insulin sensitivity (P=0.039), with this association partially explained by body mass.
  • These associations were not significantly influenced by the severity of NAFLD.

Conclusions:

  • The findings suggest a detrimental role for Sfrp5 in human insulin secretion.
  • Serum Sfrp5 has a weak association with insulin sensitivity, partly mediated by body mass.
  • The relationship between Sfrp5 and metabolic parameters in humans warrants further investigation.