Jove
Visualize
Contact Us

Related Concept Videos

Extrinsic and Intrinsic Pathways of Hemostasis01:20

Extrinsic and Intrinsic Pathways of Hemostasis

15.1K
Blood clotting or coagulation involves extrinsic and intrinsic pathways, which ultimately merge into the common pathway, forming a fibrin clot.
The Extrinsic Pathway
The extrinsic pathway of coagulation is typically initiated by tissue damage that exposes blood to tissue factor (TF), a protein released by the damaged tissue cells outside the blood vessels—this interaction with TF triggers biochemical reactions involving specific clotting factors. The key player here is Factor VII, which...
15.1K
Anticoagulant Drugs: Low-Molecular-Weight Heparins01:30

Anticoagulant Drugs: Low-Molecular-Weight Heparins

2.3K
Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
2.3K
Structure and Function of Platelets01:18

Structure and Function of Platelets

4.6K
The cell fragments known as platelets are disc-shaped, with an average diameter of about 3 μm and a thickness of roughly 1 μm. They play a crucial role in the body's vascular clotting system, which also involves plasma proteins, blood cells, and blood vessel tissues.
Platelets are continually replenished, circulating in the bloodstream for 9-12 days before being removed by phagocytes, primarily in the spleen. A microliter of circulating blood contains between 150,000 and 450,000...
4.6K
Clot Retraction and Fibrinolysis01:16

Clot Retraction and Fibrinolysis

10.1K
After a fibrin clot is formed, the next step is clot retraction, a vital process facilitated by platelet contractile proteins, such as actin and myosin. These proteins pull the fibrin strands closer together and condense the clot. This action reduces the size of the clot, creating a smaller, denser structure that effectively seals off the damaged vessel. Clot retraction consolidates the clot and helps with wound healing by bringing the edges of the damaged blood vessel closer together.
10.1K
Coagulation01:09

Coagulation

11.9K
The coagulation phase is a critical part of the body's process to prevent blood loss following injury to blood vessels. It involves chemical reactions that form a clot to seal the injured area. The clotting process begins shortly after injury, within 15-20 seconds for severe damage and 1-2 minutes for minor injuries.
During the coagulation phase, clotting factors, or procoagulants, play a vital role in initiating and progressing the coagulation cascade. This cascade is a series of reactions...
11.9K
Formation of the Platelet Plug01:22

Formation of the Platelet Plug

10.6K
The platelet phase, the second stage of hemostasis, commences around 15-20 seconds after an injury. It follows and overlaps with the vascular phase, during which blood vessels constrict to minimize blood loss.
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...
10.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Management of anticoagulation and factor XIII replacement in a patient with severe factor XIII deficiency and recurrent venous thromboembolic disease: case report and review of literature.

Research and practice in thrombosis and haemostasis·2024
Same author

Plasma levels of mannan-binding lectin-associated serine proteases are increased in type 1 diabetes patients with insulin resistance.

Clinical and experimental immunology·2023
Same author

Complement inhibition can decrease the haemostatic response in a microvascular bleeding model at multiple levels.

Frontiers in immunology·2023
Same author

Complement lectin pathway components MBL and MASP-1 promote haemostasis upon vessel injury in a microvascular bleeding model.

Frontiers in immunology·2022
Same author

Exploring the function of factor XIII free B subunit: Interactions with complement factors and a novel approach to identify potential binding partners.

Research and practice in thrombosis and haemostasis·2022
Same author

Basic science research opportunities in thrombosis and hemostasis: Communication from the SSC of the ISTH.

Journal of thrombosis and haemostasis : JTH·2022
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Mar 23, 2026

Helical Organization of Blood Coagulation Factor VIII on Lipid Nanotubes
12:24

Helical Organization of Blood Coagulation Factor VIII on Lipid Nanotubes

Published on: June 3, 2014

12.8K

Factor XIII: Structure and Function.

Verena Schroeder1, Hans P Kohler1

  • 1Experimental Haemostasis Research Group, Department of Clinical Research, University of Bern, Bern, Switzerland.

Seminars in Thrombosis and Hemostasis
|March 29, 2016
PubMed
Summary
This summary is machine-generated.

Factor XIII (FXIII) plays roles beyond blood clotting, impacting bone biology, immunity, and fat cell development. Recent research clarifies its structure and diverse cellular functions, though more study is needed.

More Related Videos

Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay
13:08

Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay

Published on: September 9, 2012

19.5K
Analyzing the Interaction of Fluorescent-Labeled Proteins with Artificial Phospholipid Microvesicles using Quantitative Flow Cytometry
08:26

Analyzing the Interaction of Fluorescent-Labeled Proteins with Artificial Phospholipid Microvesicles using Quantitative Flow Cytometry

Published on: April 6, 2022

3.0K

Related Experiment Videos

Last Updated: Mar 23, 2026

Helical Organization of Blood Coagulation Factor VIII on Lipid Nanotubes
12:24

Helical Organization of Blood Coagulation Factor VIII on Lipid Nanotubes

Published on: June 3, 2014

12.8K
Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay
13:08

Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay

Published on: September 9, 2012

19.5K
Analyzing the Interaction of Fluorescent-Labeled Proteins with Artificial Phospholipid Microvesicles using Quantitative Flow Cytometry
08:26

Analyzing the Interaction of Fluorescent-Labeled Proteins with Artificial Phospholipid Microvesicles using Quantitative Flow Cytometry

Published on: April 6, 2022

3.0K

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Background:

  • Factor XIII (FXIII) is recognized for its role in clot stabilization.
  • Emerging evidence highlights FXIII's involvement in non-hemostatic processes.
  • Understanding FXIII's structure-function relationship is crucial for elucidating its diverse roles.

Purpose of the Study:

  • To review recent advancements in the structure and function of Factor XIII (FXIII).
  • To explore FXIII's involvement in bone biology, immunity, and adipogenesis.
  • To identify areas requiring further investigation regarding FXIII's cellular functions.

Main Methods:

  • Literature review of recent studies on FXIII structure and function.
  • Analysis of findings related to FXIII subunit interactions and domain functions.
  • Examination of experimental data on FXIII's role in cellular processes.

Main Results:

  • Recent structural studies elucidate FXIII subunit assembly, highlighting the role of the activation peptide in FXIII-A2 dimer formation and Sushi domains in B subunit interactions.
  • FXIII interactions with immune cells and the complement system are described.
  • A novel function of FXIII-A in adipogenesis is suggested, while its role in osteoblast differentiation requires further clarification, as indicated by knockout mouse studies.

Conclusions:

  • FXIII possesses diverse functions extending beyond hemostasis.
  • Further research into the specific cellular roles of FXIII-A is necessary.
  • The structural insights provide a foundation for understanding FXIII's multifaceted biological activities.