Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Epigenetic Regulation

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...

Epigenetic Regulation

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Evaluating therapeutic efficacy of iopanoic acid in a DMM-induced osteoarthritis mouse model and osteochondral lesioned human explants.

Osteoarthritis and cartilage open·2026

Same author

Comparative Assessment of Cartilage Quality in Human Induced Chondrocytes (hiCHOs) and Primary Articular Chondrocytes (hACs) Following Fibronectin-Based Selection.

Cartilage·2026

Same author

Patterns and mood effects of concomitant polydrug use of ecstasy and alcohol in Dutch and British electronic dance event visitors: an EMA study.

European addiction research·2026

Same author

Application of hiPSCs for tissue modeling and therapy: are we on track?

Stem cells (Dayton, Ohio)·2026

Same author

Supramolecular Engineering of Fluid Pressure in Filamentous Hybrid Double Network Hydrogels for 3D Chondrocyte Culture.

Advanced healthcare materials·2026

Same author

HiMSC and EV derived treatments increase Quality of Life and reduce amount of Knee Replacement Surgeries compared to current standard of care for knee osteoarthritis patients in The Netherlands.

PloS one·2026

Search research articles

Related Experiment Video

Updated: Mar 23, 2026

Software-Assisted Quantitative Measurement of Osteoarthritic Subchondral Bone Thickness

Software-Assisted Quantitative Measurement of Osteoarthritic Subchondral Bone Thickness

Published on: March 18, 2022

DNA Methylation in Osteoarthritis.

Wouter den Hollander¹, Ingrid Meulenbelt¹

¹Department of Molecular Epidemiology, LUMC, Leiden, The Netherlands.

Current Genomics

|March 29, 2016

Summary

DNA methylation changes in articular cartilage are linked to osteoarthritis (OA) progression. These epigenetic alterations affect gene expression and may identify patient subgroups, offering new insights into OA pathophysiology.

Keywords:

Articular cartilage DNA methylation Data integration Osteoarthritis Transcriptomics.

More Related Videos

A 5-mC Dot Blot Assay Quantifying the DNA Methylation Level of Chondrocyte Dedifferentiation In Vitro

A 5-mC Dot Blot Assay Quantifying the DNA Methylation Level of Chondrocyte Dedifferentiation In Vitro

Published on: May 17, 2017

LINE-1 Methylation Analysis in Mesenchymal Stem Cells Treated with Osteosarcoma-Derived Extracellular Vesicles

LINE-1 Methylation Analysis in Mesenchymal Stem Cells Treated with Osteosarcoma-Derived Extracellular Vesicles

Published on: February 1, 2020

Related Experiment Videos

Last Updated: Mar 23, 2026

Software-Assisted Quantitative Measurement of Osteoarthritic Subchondral Bone Thickness

Software-Assisted Quantitative Measurement of Osteoarthritic Subchondral Bone Thickness

Published on: March 18, 2022

A 5-mC Dot Blot Assay Quantifying the DNA Methylation Level of Chondrocyte Dedifferentiation In Vitro

A 5-mC Dot Blot Assay Quantifying the DNA Methylation Level of Chondrocyte Dedifferentiation In Vitro

Published on: May 17, 2017

LINE-1 Methylation Analysis in Mesenchymal Stem Cells Treated with Osteosarcoma-Derived Extracellular Vesicles

LINE-1 Methylation Analysis in Mesenchymal Stem Cells Treated with Osteosarcoma-Derived Extracellular Vesicles

Published on: February 1, 2020

Area of Science:

Epigenetics
Molecular Biology
Rheumatology

Background:

Osteoarthritis (OA) is a degenerative joint disease characterized by cartilage degradation.
Current treatments primarily manage pain, with joint replacement surgery often being the ultimate solution.
Chondrocytes in OA exhibit altered gene expression and phenotypic changes resembling terminal differentiation.

Purpose of the Study:

To investigate the role of DNA methylation in osteoarthritis pathophysiology.
To explore how epigenetic changes influence gene expression in OA.
To identify potential OA patient subgroups and pathways using genome-wide methylation profiling.

Main Methods:

Targeted gene analysis of known OA-related genes.
Genome-wide DNA methylation profiling of articular cartilage from OA patients.
Correlation of methylation patterns with gene expression and OA susceptibility alleles.

Main Results:

DNA methylation changes are associated with aberrant gene expression in OA.
Specific OA susceptibility alleles (e.g., GDF5, DIO2) confer risk through DNA methylation.
Genome-wide analysis identified novel OA-associated pathways and potential patient stratification markers.

Conclusions:

DNA methylation plays a significant role in mediating gene expression changes during OA development.
Epigenetic profiling provides a comprehensive view of OA-associated molecular alterations.
Understanding these epigenetic mechanisms may lead to novel therapeutic strategies and patient stratification for osteoarthritis.