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Effect of Kuijie Granule on the Expression of TGF-β/Smads Signaling Pathway in Patients with Ulcerative Colitis

Xinjie Xu1, Chunhua Xu2, Shakir M Saud3

  • 1Traditional Chinese Medicine Department, Affiliated Hospital of Taishan Medical University, Shandong 271000, China.

Evidence-Based Complementary and Alternative Medicine : Ecam
|March 29, 2016
PubMed

Insights

Kuijie Granule alleviates ulcerative colitis (UC) symptoms by modulating the transforming growth factor-beta (TGF-β)/Smads signaling pathway. Treatment reduced key inflammatory markers, improving patient outcomes.

Area of Science:

  • Gastroenterology
  • Molecular Biology
  • Pharmacology

Background:

  • Ulcerative colitis (UC) is linked to dysregulation of the TGF-β/Smads signaling pathway.
  • Kuijie Granule is a Chinese herbal medicine used to manage UC symptoms.

Purpose of the Study:

  • To investigate the effect of Kuijie Granule on TGF-β/Smads signaling in UC patients.
  • To correlate clinical improvements with changes in TGF-β/Smads protein expression.

Main Methods:

  • 72 UC patients received Kuijie Granule for 60 days.
  • Colonic biopsies were analyzed pre- and post-treatment using immunohistochemistry.
  • Expression levels of TGF-β1, TGF-βRII, Smad2, Smad4, Smad6, and Smad7 were quantified.

Main Results:

  • Kuijie Granule significantly improved UC symptoms including diarrhea, bleeding, and pain.
  • Treatment led to decreased TGF-β1 and Smad7 expression.
  • Increased expression of TGF-βRII and Smad4 was observed post-treatment.

Conclusions:

  • Kuijie Granule demonstrates clinical efficacy in alleviating UC symptoms.
  • The therapeutic effect is associated with the modulation of the TGF-β/Smads signaling pathway.

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