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Updated: Mar 23, 2026

ALS - Motor Neuron Disease: Mechanism and Development of New Therapies
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Quo vadis motor neuron disease?

Rubika Balendra1, Rickie Patani1

  • 1Rubika Balendra, Department of Neurodegenerative Disease, Institute of Neurology, University College London, London WC1N 3BG, United Kingdom.

World Journal of Methodology
|March 29, 2016
PubMed
Summary

Motor neuron disease (MND), or amyotrophic lateral sclerosis, is a fatal neurodegenerative condition with no cure. This review explores MND mechanisms and discusses strategies for developing effective treatments.

Keywords:
Amyotrophic lateral sclerosisDisease modelsMotor neuron diseaseNeurodegeneration

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Area of Science:

  • Neurodegenerative diseases
  • Neurobiology
  • Neurology

Background:

  • Motor neuron disease (MND), also known as amyotrophic lateral sclerosis (ALS), is a progressive, fatal neurodegenerative disorder.
  • Current understanding of MND's etiology and pathogenesis is incomplete, with no definitive cure available.
  • Riluzole, a glutamate antagonist, is the sole FDA-approved therapy, offering modest survival benefits.

Purpose of the Study:

  • To provide a comprehensive overview of the motor system's anatomy and its dysfunction in MND.
  • To summarize current knowledge on MND pathogenesis derived from pathological, genetic, and animal studies.
  • To propose strategies for accelerating the discovery of novel therapeutic targets for MND.

Main Methods:

  • Review of existing literature on motor system anatomy and MND.
  • Analysis of pathological findings in MND.
  • Examination of genetic factors implicated in MND.
  • Evaluation of insights from animal models of MND.

Main Results:

  • The review details the structural and functional organization of the motor system.
  • It highlights key clinical features and progression patterns of MND.
  • Insights from diverse research avenues underscore the complexity of MND.

Conclusions:

  • There is a critical unmet need for effective treatments for MND.
  • Understanding disease mechanisms is paramount for developing novel therapeutic strategies.
  • A multi-faceted approach combining pathological, genetic, and model system insights is crucial for advancing MND research.