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Nucleic acid-functionalized transition metal nanosheets for biosensing applications
Liuting Mo1, Juan Li2, Qiaoling Liu1
1Molecular Sciences and Biomedicine Laboratory, State Key Laboratory for Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering and College of Biology, Collaborative Innovation Center for Molecular Engineering and Theranostics, Hunan University, Changsha 410082, China.
This review highlights nucleic acid-functionalized 2D transition metal nanosheets for biosensing. These advanced biosensors offer enhanced detection capabilities for various applications in diagnostics and safety.
Area of Science:
- Materials Science
- Biotechnology
- Analytical Chemistry
Background:
- Biosensors are crucial for clinical diagnostics, food, and environmental safety.
- Two-dimensional (2D) transition metal nanomaterials (TMCs, TMOs) offer unique properties like high surface area for biosensing.
- Nucleic acids, especially aptamers, provide excellent target recognition capabilities.
Purpose of the Study:
- To review recent advances in nucleic acid-functionalized 2D transition metal nanosheets for biosensing.
- To discuss the structure, properties, and interactions between these materials and nucleic acids.
- To explore applications based on optical and electrochemical signal transduction.
Main Methods:
- Review of literature on 2D transition metal nanomaterials and nucleic acid interactions.
- Analysis of π-π stacking interactions for biosensor assembly.
- Discussion of optical and electrochemical signal transduction mechanisms in biosensors.
Main Results:
- Nucleic acid-functionalized 2D transition metal nanosheets demonstrate significant potential in bioanalysis.
- These biosensing systems leverage unique nanomaterial properties and nucleic acid recognition.
- Applications span diverse targets including small molecules, ions, proteins, and cells.
Conclusions:
- The combination of 2D transition metal nanomaterials and nucleic acids presents promising opportunities in bioanalysis and biomedicine.
- Further research is needed to address current challenges and explore future potential in this field.
