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Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
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Introduction to skin aging.

Desmond J Tobin1

  • 1Centre for Skin Sciences, Faculty of Life Sciences, University of Bradford, Bradford, West Yorkshire BD7 1DP, UK.

Journal of Tissue Viability
|March 30, 2016
PubMed
Summary
This summary is machine-generated.

Human skin aging is influenced by factors like reactive oxygen species and hormonal changes. Harnessing the regenerative power of hair follicles offers new strategies for optimal skin repair and quality of life.

Keywords:
AgingDermisEpidermisPhotoagingSkin

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Area of Science:

  • Cutaneous science
  • Dermatology
  • Aging research

Background:

  • The skin's role in neuro-immuno-endocrine axes is increasingly recognized.
  • Stratification of skin disorders enables targeted treatments.
  • Increased lifespan correlates with rising lifestyle-associated conditions like diabetes and skin cancer.

Purpose of the Study:

  • To review human skin aging mechanisms.
  • To explore strategies for enhancing skin repair and regeneration.
  • To highlight the role of hair follicles in skin regeneration.

Main Methods:

  • Review of current literature on skin aging.
  • Analysis of molecular and cellular mechanisms of skin aging.
  • Discussion of stem cell populations in skin regeneration.

Main Results:

  • Key aging mechanisms include reactive oxygen species, mtDNA mutations, and telomere shortening.
  • Hormonal changes significantly impact skin aging.
  • Hair follicles possess substantial regenerative potential due to diverse stem cell populations.

Conclusions:

  • Maintaining skin function is crucial for quality of life in aging populations.
  • Targeting skin's regenerative capacity, particularly via hair follicles, is a promising therapeutic avenue.
  • Understanding skin aging is vital for developing effective clinical solutions.