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Updated: Mar 23, 2026

Improved Rodent Model of Myocardial Ischemia and Reperfusion Injury
Published on: March 7, 2022
Free Radical Oxidation in Rat Myocardium after Maximum Permissible Hepatic Resection
P A Ermolaev1, T P Khramykh2, L O Barskaya2
1Omsk State Medical University, Ministry of Health of the Russian Federation, Omsk, Russia. yermol@inbox.ru.
Abstract:
Free radical oxidation in rat myocardial homogenate was studied by chemiluminescent assay during the early terms after maximum permissible liver resection. During this period, activation of free radical oxidation was biphasic. The critical terms characterized by dramatic intensification of free radical oxidation in the myocardium are the first hour and the first day after surgery. The period from 3 to 12 h after surgery, in which the indices of chemiluminescence decrease, can be tentatively termed as the period of "putative wellbeing". Normalization of the free radical oxidation processes in the myocardium occurred by day 7 after surgery.

